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Common painkiller may shield brain during lung operations

NCT ID NCT07399184

Symptom relief Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving ibuprofen during and right after lung surgery can help keep the brain well-oxygenated and lower the risk of confusion or memory problems afterward. About 54 adults having a type of keyhole lung surgery will be split into two groups: one gets ibuprofen, the other does not. Researchers will measure brain oxygen levels during surgery and check for delirium and thinking changes after.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-75 years * American Society of Anesthesiologists (ASA) Physical Status Classification System I-III * Patients scheduled for lobectomy or segmentectomy via Video-Assisted Thoracic Surgery (VATS ) with one-lung ventilation * New York Heart Association (NYHA) class I-II * Patients who have been informed about the study and have provided written informed consent will be included. Exclusion Criteria: * Patients younger than 18 years or older than 75 years * History of alcohol or substance abuse * Patients with chronic NSAID use and/or NSAID use within the last 30 days, or NSAID allergy * Allergy to other drugs used in the study (e.g., bupivacaine) * ASA Physical Status IV-V * Severe hearing, visual, or speech impairment * Dementia, Alzheimer's disease, or psychiatric disorders (psychosis, bipolar disorder, schizophrenia) * History of previous head trauma * Chronic liver disease * Pregnancy * History of cerebrovascular disease * Moderate-to-severe chronic obstructive pulmonary disease (COPD) (predicted FEV₁ \<50%) * GFR \<60 mL/min/1.73 m² * Patients who do not provide written informed consent * Conditions that may cause inaccurate cerebral oximetry readings (subdural and/or extracranial hematoma, intracranial arteriovenous shunts, hyperbilirubinemia) * Patients undergoing emergency surgery * Patients in whom surgery is initiated as thoracotomy or converted to thoracotomy * Patients unable to complete the preoperative MMSE (total score ≤24) will be excluded.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral oxygen saturation Postoperative cognitive dysfunction (POCD) Postoperative delirium

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.