PERIPHERAL ARTERY DISEASE

This study compares two balloon treatments used after placing a stent in long blockages (over 10 cm) in the leg arteries of people with peripheral artery disease. One balloon is coated with a drug to help keep the artery open, while the other is a standard balloon. The goal is to…

This study tests a device called the Thor system in 155 adults with peripheral artery disease (PAD) who have new blockages in their leg arteries. The goal is to see if the device is safe and works well to open the blocked arteries. Participants will get the treatment and be follo…

This study is testing a special balloon coated with medicine to open blocked arteries below the knee in people with severe leg artery disease (chronic limb-threatening ischemia). The goal is to improve blood flow, avoid amputation, and keep arteries open longer. About 1000 partic…

This study looks at whether combining a weight loss program with a walking exercise plan helps people with peripheral artery disease (PAD) and overweight walk farther after 12 months, compared to just walking exercise alone. About 212 adults with PAD and a BMI over 25 will take p…

This study compares two ways to deliver a home walking program for veterans with peripheral artery disease (PAD), a condition that causes leg pain when walking. About 225 participants will either get a web-based program, a telehealth program, or usual care. The goal is to see whi…

This study tests a home-based exercise program for Veterans with peripheral artery disease (PAD), a condition that limits walking and raises amputation risk. Participants use a wearable activity monitor and join group coaching sessions to improve their walking ability. The goal i…

This study tests whether a single dose of the drug diroximel fumarate (Vumerity) can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to poor blood flow. Researchers will give 20 participants …

This study tests a program for people with leg pain caused by peripheral artery disease (PAD). Participants will get up to four remote physiotherapy sessions and a small device that uses mild electrical pulses to reduce leg pain during walking. The goal is to see if this approach…

This study tests whether drinking beetroot juice for four months helps people with peripheral artery disease (PAD) walk farther. PAD narrows leg arteries, causing pain and difficulty walking. The trial will compare beetroot juice to a placebo in 210 adults aged 50 and older, meas…

This study tests whether a community-based exercise program can improve walking ability and heart health in people with peripheral artery disease (PAD) who have had a procedure to open blocked leg arteries. About 30 participants will take part. The goal is to see if this type of …

This study tests whether combining the DASH diet (a heart-healthy eating plan) with a home-based walking program can help people with peripheral artery disease (PAD) walk longer and feel better. About 150 adults with PAD and leg cramps will follow the program for 3 months. The go…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over age 50 with PAD will use heated trousers at home for 90 minutes each day. Researchers will measure changes in walk…

This study tests two walking training programs to help veterans with leg amputation walk more evenly. It includes 54 veterans who have lost a leg below the knee due to diabetes or artery disease. The goal is to improve walking symmetry, reduce pain, and prevent long-term disabili…

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), where leg arteries are blocked and walking becomes painful. The program uses muscle oxygen levels to guide exercise, aiming to help patients walk farther and reduce muscle damage. …

This study tests whether shining a specific red light on the legs each day before a walking workout can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to narrowed arteries. The trial will involve 32 adults aged 50 and…

This study looks at how leg artery disease (LEAD) might affect the heart's pumping ability. Researchers will use ultrasound imaging to measure heart function in 162 participants with and without LEAD. The goal is to find connections between heart strain, metabolism, and organ dam…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to look for biological markers that could help understand these conditions better. The goal is to support…

This study looks at how often sleep apnea occurs in people with peripheral artery disease (blocked arteries in the legs). About 295 adults with confirmed leg artery disease will have a sleep test as part of their routine care. The goal is to better understand the connection betwe…

This study follows 2,000 people with chronic coronary artery disease who are taking long-term blood thinners. Researchers will track how often serious heart events (like heart attacks or strokes) and bleeding problems occur. The goal is to better understand the balance of risks a…

This study is testing whether a single 5-minute exposure to a specific type of light (670 nm) can increase blood flow in the calf muscles of people with peripheral artery disease (PAD). Researchers will measure blood flow using ultrasound and take blood samples to check for nitri…

This study is testing a new, advanced ultrasound technique that can see tiny blood vessels in the legs. Researchers want to know if this imaging can help predict future problems in people with peripheral artery disease (PAD). About 300 adults with PAD will get this special ultras…

This study looks at whether a passive leg-paddling motion (LEAP therapy) during 2.5 hours of sitting can improve blood flow and walking ability in people with peripheral artery disease (PAD) and in healthy older adults. About 24 participants will each try both sitting with LEAP t…

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…