PERIPHERAL ARTERY DISEASE

This study is observing how well a special drug-coated balloon works to open blocked arteries below the knee in patients with severe leg pain or wounds that won't heal. It will follow 1,000 patients for a year to see if the procedure improves blood flow, helps wounds heal, and pr…

This study is testing a new medical device called the THOR system to see if it is safe and effective at opening up hardened blockages in the leg arteries of people with peripheral artery disease (PAD). About 155 adults with leg pain from poor blood flow will have the procedure an…

This VA study is testing a new way to guide exercise therapy for veterans with peripheral artery disease (PAD), where blocked leg arteries cause painful cramping when walking. Instead of using pain to decide when to stop and rest, the new method uses a sensor to monitor oxygen le…

This small, early-stage study is testing whether a low dose of the anti-inflammatory drug colchicine can reduce inflammation in the leg arteries of people with peripheral artery disease. Researchers will compare 24 patients taking colchicine for four weeks to those taking a place…

This study is testing whether a computer alert in the medical record system can help doctors prescribe cholesterol-lowering medications to patients with peripheral artery disease (PAD) who are not currently on treatment. The alert reminds both doctors and patients about guideline…

This study is testing whether a new type of ultrasound imaging can better predict which patients with peripheral artery disease (PAD) are at risk for serious complications like limb loss or heart problems. Researchers will use this advanced imaging to look at tiny blood vessels i…

This early-stage study is testing if a single dose of the drug diroximel fumarate (Vumerity) can improve blood vessel function and walking capacity in people with peripheral artery disease (PAD). Researchers will give 20 participants either the drug or a placebo and measure chang…

This study is testing whether a simple, at-home leg warming treatment can help people with peripheral artery disease (PAD) walk farther and feel better. About 106 participants will use special water-circulating trousers daily for three months, with half receiving warm water and h…

This study is testing a new, gentle leg movement therapy for people with peripheral artery disease (PAD), a condition that causes poor blood flow and pain in the legs. Researchers want to see if moving the legs passively (without muscle effort) during long periods of sitting can …

This study is testing two new walking training programs designed to help Veterans with leg amputation from diabetes or poor circulation walk more evenly. Researchers want to see if these training methods, which give specific feedback about walking patterns, can improve balance, r…

This study is testing a convenient home exercise program for Veterans with peripheral artery disease (PAD), which causes painful leg cramps when walking. Instead of traveling to a clinic, participants will use a wearable activity monitor and get remote coaching to follow a walkin…

This study is testing whether a guided, community-based walking program helps people with peripheral artery disease (PAD) walk farther and feel better after having a procedure to improve blood flow in their legs. Researchers will compare a group that gets coaching and support for…

This study is testing if a home-based program can help people with leg pain from poor circulation (intermittent claudication) become more active. Researchers want to see if four video calls with a physical therapist, plus a small electrical device to reduce leg pain during walkin…

This study aims to better understand how lower leg artery disease (LEAD) affects heart function. Researchers will observe 162 people, some with LEAD and some without, using detailed heart scans and blood tests. The goal is to learn how these conditions are connected to help impro…

This study aims to find out how common obstructive sleep apnea is in people who have peripheral artery disease (narrowed leg arteries). Researchers will observe about 295 adults with artery disease, using a simple sleep test to check for apnea. The goal is to gather information a…

This study aims to create a long-term collection of biological samples to help researchers better understand heart and blood vessel diseases. It will collect blood, urine, and stool samples from 500 adults who have or are at risk for these conditions. The goal is to build a share…