PERIPHERAL ARTERY DISEASE

This study followed 50 people who had a procedure to clear severely blocked leg arteries (peripheral artery disease). Doctors used a special device to remove plaque (Jetstream) and then a drug-coated balloon (Ranger) to keep the artery open. The goal was to see how many patients …

This study tested a device called the Orbital Atherectomy System in 81 Japanese adults with hardened blockages in their leg arteries (peripheral artery disease). The device grinds away calcium buildup to restore blood flow, avoiding more invasive procedures. The goal was to see i…

This study tested a device that uses sound waves to break up calcium buildup in the leg arteries below the knee. The goal was to improve blood flow and reduce the risk of serious problems like amputation. The study included 250 adults with severe peripheral artery disease, and th…

This study tested a special balloon coated with sirolimus, a drug that helps keep arteries open, in 34 people with peripheral artery disease (blocked leg arteries). The goal was to see if the balloon is safe and works well at preventing the artery from narrowing again after treat…

This study looked at how well simple bedside tests (like using a Doppler device or checking blood pressure in the ankle and toe) can detect poor leg circulation in people with diabetes. Poor circulation is a major cause of leg amputations in diabetes. The study involved 604 adult…

This study tested whether a physical activity program delivered by mail and phone could help older women prevent serious health problems like heart attacks, strokes, hip fractures, and falls. About 50,000 women already in the Women's Health Initiative took part. The program provi…

This study tested whether specially designed shoes (carbon fiber or spring-loaded) could help people with peripheral artery disease walk farther and more comfortably. Ten veterans with blocked leg arteries tried the shoes for three months. The goal was to see if the shoes were co…

This small study tested whether a gentle electrical pulse to the ear (transcutaneous vagal stimulation) could improve blood vessel function in 11 people with peripheral artery disease (PAD). The approach aims to calm the nervous system and reduce inflammation, potentially helping…

This small pilot study tested whether taking a daily NAD supplement for 4 weeks could improve blood vessel function, brain blood flow, and thinking skills in 8 older adults with peripheral artery disease (PAD). Researchers measured changes in artery health, cognitive tests, and b…

This study tested whether taking metformin daily for six months helps people with peripheral artery disease (PAD) walk farther in six minutes. About 200 adults with PAD took either metformin or a placebo. The main goal was to see if metformin improves walking performance, which c…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the leg arteries of people with peripheral artery disease (PAD). 24 adults with PAD received either colchicine or a placebo. Researchers used special scans and blood tests to measure inflammati…

This study looked at whether asking people to "opt in" or "opt out" changes how many patients with peripheral artery disease (PAD) join a physical activity trial. Over 5,000 adults with PAD were contacted by email. The goal was to see which framing leads to more enrollments and w…

This study looked at whether using telemedicine (video or phone calls) helps people with hard-to-heal leg wounds in rural areas see a specialist faster than going in person. About 116 adults with leg ulcers from conditions like diabetes or poor blood flow took part. Researchers m…

This study looked at how a special balloon coated with a drug (sirolimus derivative) releases medication into the leg arteries of people with peripheral artery disease. Six participants were enrolled at one site in Australia. The goal was to measure drug levels in the blood over …