OROPHARYNX CANCER

This study tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery, as guidelines recommend. About 532 adults with certain types of head and neck cancer will take part. The program uses patient navigators to guid…

This study tests whether a single dose of a patient's own genetically modified immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before standard treatment like chemo-radiation or surgery. About 15 adults with advanced HPV-positive cancers (e.g., cervical, …

This study is for people with certain head and neck cancers (oropharynx, larynx, hypopharynx) that haven't spread past the midline. It tests two ideas: using a smaller radiation target to reduce side effects, and adding the drug ATRA to help prevent the cancer from coming back. A…

This study is for people with HPV-related throat cancer who have had or will have surgery to remove the tumor. Researchers will use a blood test to look for tiny bits of cancer DNA (ctDNA) to see if the cancer is likely to come back. The goal is to find out if some patients can s…

This study is testing whether taking three oral drugs (methotrexate, erlotinib, and celecoxib) together is safe and practical for people with head and neck cancer that has come back or spread. The trial focuses on patients in rural Midwest areas, aiming to make treatment more acc…

This study tests whether using a special scan (lymphoscintigraphy) to guide radiation only to the side of the neck with cancer can prevent the cancer from spreading to the other side while reducing dry mouth. About 22 adults with HPV-positive oropharynx cancer that has not spread…

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Doctors take a patient's own immune cells, add a special receptor to help them find and attack HPV-infected cancer cells, and give them back. The goal is to shr…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has gotten worse after first-line therapy. About 40 adults with certain types of head and neck cancer will receive the drug combi…

This study is for people with HPV-related throat cancer. It uses a special PET scan during treatment to see if the cancer is responding well. If it is, doctors will give a lower dose of radiation. The goal is to see if this lower dose still works well and causes fewer side effect…

This study is for people with oropharynx cancer who need radiation. It tests whether giving radiation to a smaller area of the neck can lower side effects without increasing the risk of cancer coming back. About 120 participants will receive personalized radiation plans based on …

This study looks at whether people with HPV-positive throat cancer who had surgery can safely receive a lower radiation dose to a smaller area (just the neck, not the original tumor site). The goal is to keep the cancer from coming back while reducing side effects. About 30 adult…

This study tests a new surgical technique using a skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if this method causes fewer complications at the donor site compared to standard flaps. About 40 adults with head and neck cance…

This study looks at whether a simple blood test can tell which throat cancer patients can safely skip radiation after surgery. About 61 people with HPV-related throat cancer will have their blood tested before and after surgery. If the test is negative after surgery, they won't g…

This study aims to find out how many healthy adults over 40 in the Czech Republic have high-risk HPV in their mouth, which can lead to throat cancer. Researchers will test 20,000 volunteers using a simple mouth rinse. The goal is to develop a better, more practical screening meth…