ORAL CANCER

This study tests whether using ultrasound during oral cancer surgery helps surgeons remove tumors more completely. About 150 adults with early-stage oral cancer will be randomly assigned to standard surgery or surgery guided by ultrasound. The goal is to see if ultrasound leads t…

This study tests whether a short course of antibiotics (metronidazole) and mouthwash (chlorhexidine) can lower the amount of bacteria living inside oral cancer tumors. About 30 adults scheduled for oral cancer surgery will receive the treatment before their operation. Researchers…

This study compares two non-invasive methods—a cell-collection brush test and a special microscope—to detect early mouth cancer and precancer. Researchers will enroll 400 adults with visible mouth lesions to see if these tools can better decide which lesions need a biopsy. The go…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether a custom dental device called a palatal augmentation prosthesis (PAP) can improve speech after surgery for small tongue cancers (T1 or T2). About 40 participants will be randomly assigned to receive the device or standard care. Researchers will measure ho…

This study tests whether starting a tongue strengthening exercise program soon after tongue cancer surgery can improve speech and swallowing. About 40 adults who have part of their tongue removed will use a biofeedback device called the Tongueometer to do the exercises. The goal …

This study tests two pain medicines, dezocine and nalbuphine, given with a standard opioid after oral cancer surgery. The goal is to find which combination controls pain better, causes fewer side effects like nausea, and helps the surgical flap heal. Sixty adults aged 18 to 70 ha…

This study tests whether an AI-powered physiotherapy app can help oral cancer patients regain jaw movement, shoulder function, and overall physical ability after surgery, chemo, or radiation. One hundred adults aged 20-65 will be split into two groups: one using the AI app for 12…

This study is testing a smartphone app powered by artificial intelligence to help people with oral cancer return to work and manage physical and emotional challenges. Researchers will compare 650 patients who use the app with those who receive standard care. The goal is to see if…

This study follows oral cancer patients who completed a previous rehabilitation trial. It compares AI-based physiotherapy to standard physiotherapy to see which better improves jaw movement, shoulder function, overall physical health, quality of life, and return to work. Research…

This study looks at whether a simple blood test that finds leftover cancer cells (circulating tumor cells) can help doctors decide if oral cancer patients need extra chemotherapy after their usual treatment. About 100 people who have finished surgery and chemoradiation for oral c…

This study will follow 40 people having standard oral cancer surgery to understand why some get infections. Researchers will track bacteria from the mouth, nose, and throat to see where infections come from. They will also measure antibiotic levels in tissues and blood. The goal …

This study will develop an AI system to measure how well people can move their jaw, neck, and shoulders. Researchers will compare the AI's measurements to standard methods in 40 healthy adults and oral cancer patients who have trouble moving these areas after treatment. The goal …

This study checks if an AI-based system can accurately measure jaw and neck-shoulder movement in 20 healthy adults, compared to traditional manual methods. The goal is to see if the AI can provide more consistent and objective measurements for oral cancer patients. If successful,…

This study tests whether an AI-powered chatbot can help African American adults learn more about oral cancer and its prevention compared to traditional educational handouts. About 60 participants will be split into two groups, and their knowledge will be measured before and after…

This study looks at how stiff the jaw muscles are in people who have had treatment for oral cancer, and whether that stiffness is linked to how wide they can open their mouth. Researchers will use a special ultrasound to measure muscle hardness and then see if exercise training c…

This study aims to understand why oral cancer hurts by comparing pain sensitivity between 40 oral cancer patients and 40 healthy volunteers. Researchers will measure how much pressure and tongue stretching causes pain. The goal is to learn more about the role of certain nerve cel…

This study looks at whether an imbalance in the natural bacteria in your mouth and gut (called dysbiosis) plays a role in head and neck cancer. Researchers will collect stool and saliva samples from 60 adults—some with cancer and some without—to compare their microbiomes. The goa…

This study is collecting tissue samples and symptom reports from 1,000 people with oral cancer or pre-cancer. Researchers want to find biological markers that can predict how the disease will behave and how well a patient will respond to treatments like surgery, chemo, or immunot…