ONCOLOGY

This early-phase study tests a new daily pill, TRE-515, in adults with advanced solid tumors that no longer respond to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also measure how the drug moves through the body and loo…

This early-phase trial tests an experimental oral drug, NST-628, in adults with advanced solid tumors that have specific genetic changes in the MAPK pathway and have stopped responding to standard treatments. The study aims to find a safe dose and check for early signs of tumor s…

This study is testing a new imaging agent (GEH200520/GEH200521) that uses a PET scan to take pictures of solid tumors. In the first part, researchers check the safety of the agent in 50 adults with advanced cancer. In the second part, they use the agent to see if tumors change af…

This study tests whether a taurolidine lock solution, placed inside the catheter when not in use, can prevent infections better than a standard saline lock. About 148 children with cancer who need a central catheter will take part. The study is double-blind, meaning neither the p…

This study tests whether a simple card game, called the Go Wish Game, can help people with advanced blood cancers or solid tumors talk about their end-of-life priorities with their doctors. About 75 adults will play the game and then fill out advance care planning documents. The …

This study tests a non-drug light treatment called photobiomodulation to see if it can improve memory and thinking problems (chemobrain) in women who had chemotherapy for breast cancer. About 200 women who finished chemo less than a year ago and still have cognitive complaints wi…

This study tests whether an internet-based parent-child therapy program (I-PCIT) can help improve behavior in children aged 2-12 who have or had cancer. Parents of 300 children will be randomly assigned to start therapy right away or wait 5-6 months. The goal is to see if the pro…

This study looks at whether special beauty and skincare sessions (called adapted oncoesthetics) can help people with head and neck cancer feel better about their appearance after treatment. About 55 patients will try these sessions early in their care. The goal is to see if this …

This study tests a new approach called STEP2, which uses online symptom screening to decide which advanced cancer patients need a palliative care referral. It compares this targeted method to giving everyone a routine referral. The goal is to see if STEP2 works just as well at im…

This study tests a mobile health app designed to help children aged 9-16 who have recently finished cancer treatment manage symptoms like fatigue, anxiety, and pain. The app also provides personalized nurse support. Researchers will check if children using the app feel better and…

This study tests whether adding olanzapine, a safe and inexpensive drug already used in children for other conditions, to standard anti-nausea medicines can better control vomiting in 200 children receiving strong chemotherapy. The goal is to reduce one of the most distressing si…

This study is testing whether giving certain cancer immunotherapy drugs over a shorter time is still safe. About 776 adults starting treatment with drugs like nivolumab or pembrolizumab will have their infusion times gradually shortened if they tolerate it well. The main goal is …

This study tests a new type of ureteric stent designed to cause less pain, infection, and blockage than standard stents. About 50 adults who need a stent for kidney stones or cancer will receive the new stent and be monitored for complications. The goal is to see if the new stent…

This study looks at whether using a walking platform every day can help people aged 65 and older regain their normal walking speed after cancer surgery. About 60 participants will use the platform during their hospital stay. The goal is to see if this simple activity helps them r…

This study looks at how well people with conditions like cerebral palsy or cancer tolerate a new blended tube feed. Up to 50 participants will use the feed for 28 days, and researchers will track symptoms like reflux, vomiting, and diarrhea. The goal is to see if the feed is easy…

This study tests whether using a goal-setting tool helps children and teens maintain their physical abilities during a stem cell transplant. About 176 participants will be randomly assigned to either standard care or a program that sets personalized functional goals. The aim is t…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their treatment plans. Researchers will enroll 3,100 adults with cardiovascular, endocrine, immune, neurological, cancer, or rare diseases across Europe. The goal is…

This study looks at why some cancer patients develop autoimmune problems after treatment with immune checkpoint inhibitors. Researchers will analyze blood samples and health records from 600 adults with cancer who are prescribed these drugs. The goal is to find genetic and immune…

This study records short videos and voice clips of 200 cancer patients (some in pain, some not) to create a secure database. The goal is to help future artificial intelligence tools learn how to recognize pain from facial expressions and speech. No new treatments or tests are inv…

This study follows over 1,500 cancer patients in China to see how their nutritional status during chemotherapy and radiation affects their quality of life, treatment side effects, and survival. Researchers will track changes in diet, weight, and blood markers over time. The goal …

This study tests a new AI tool that turns complex radiology reports into easy-to-understand summaries for cancer patients. Researchers will ask 2,000 patients and their doctors how clear the summaries are and whether they reduce the number of questions doctors get. The goal is to…

This study is collecting information from 500 people who need a second round of high-dose radiation for lung or other chest cancers. The goal is to learn how to give this treatment more safely by tracking side effects and survival. Researchers hope the findings will help doctors …

This study looks at whether a community-based program can help cancer survivors and their loved ones eat healthier and exercise more. About 100 adults in the Birmingham area who have had cancer or are close to a cancer survivor will take part. The program adapts proven health tip…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with acute myeloid leukemia and their caregivers make informed treatment decisions. About 1,020 participants will be randomly assigned to use the tool or receive standard information. The main goal i…

This study follows 3,000 adult cancer patients who take oral anticancer drugs at home. Researchers want to understand how well these drugs work in real life and identify any problems, like side effects or dosing issues. The goal is to improve patient care and safety through bette…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study looks at how a financial counseling program for cancer patients affects their money stress, quality of life, and emotional distress. Researchers will review surveys and medical records from about 40 patients and staff at the University of Alabama at Birmingham. The goa…

This study looks at how people with advanced cancer feel about stopping medications that may no longer be helpful. Many patients take multiple drugs, which can cause side effects and lower quality of life. Researchers will interview about 325 patients and use questionnaires to un…

This study tests a program called CTNow that helps cancer patients and doctors in rural areas learn more about clinical trials. The program uses education and teleconference tools to make it easier for patients to find and join trials. About 50 adults with cancer from Hawaii, Kau…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long-term. Researchers want to know if women use their stored eggs or tissue, have natural pregnancies, or decide not to have children. The goal is to improve care and support …

This study gathers information from 15,000 cancer patients to see how well the healthcare system works. It looks at how quickly patients get diagnosed, treated, and supported. No new drugs or treatments are given. The goal is to find ways to make cancer care faster and more effic…

This study looks at how body position and the type of anesthesia used during robotic surgery for gynecologic cancer affect pressure inside the eye. About 40 women will take part. The goal is to see if using only IV anesthesia keeps eye pressure lower than standard anesthesia, whi…

This study follows 200 adults with solid tumors who are starting immunotherapy (checkpoint inhibitors). Researchers collect blood and tissue samples before and during treatment to understand why some patients develop immune-related side effects. The goal is to find early warning …