MULTIPLE SYSTEM ATROPHY

This early-stage study tests a new drug called ION464 in 40 adults with multiple system atrophy (MSA), a rare brain disease that affects movement and balance. The main goal is to check if the drug is safe and tolerable when given as a spinal injection. Researchers will also measu…

This study tests a new drug called YA-101 in 75 people with multiple system atrophy (MSA), a rare brain disease that affects movement and body functions. The goal is to see if the drug is safe and can help control the disease. Participants will receive either YA-101 or a placebo,…

This study tests an oral medication called TEV-56286 in 350 adults with multiple system atrophy (MSA), a rare and serious brain disorder. The goal is to see if the drug can slow disease progression and improve daily function over 48 weeks. Participants will be randomly assigned t…

This program gives people with multiple system atrophy (MSA) who finished a previous Phase 2 study the chance to keep taking the experimental drug ATH434. The goal is to see if continued treatment helps control the disease. Only patients whose doctors believe they may benefit can…

This study offers expanded access to an experimental stem cell treatment for up to 7 people with Multiple System Atrophy (MSA), a rare and serious brain disorder. Participants will receive 12 intravenous infusions and 6 spinal injections of donor stem cells over 44 weeks. The goa…

This study tests the long-term safety of an oral drug called TEV-56286 for adults with multiple system atrophy (MSA), a rare and serious brain disorder. About 200 people who completed a prior study will take the drug for up to 100 weeks. The main goal is to see if the drug is saf…

This early-stage study tests whether implanting a small piece of the participant's own leg nerve into a key brain area is safe and feasible for people with early Parkinson's disease or Multiple System Atrophy. Seven volunteers will take part; four will receive the nerve graft and…

This early study tests a nasal spray called foralumab in 5 adults with Multiple System Atrophy (MSA), a rare brain disease that gets worse over time. The goal is to see if the drug can calm overactive immune cells in the brain and slow down the disease. Participants will be monit…

This study uses artificial intelligence to analyze facial expressions and speech patterns in people with Parkinson's disease and related conditions. The goal is to create a digital tool that helps doctors diagnose and tell apart these disorders more accurately. Researchers will c…

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime blood pres…

This study tests whether a special swallowing exercise program can help people with multiple system atrophy (MSA) who have trouble swallowing. About 24 adults with MSA and swallowing problems will be randomly assigned to receive the therapy or usual care. The goal is to see if th…

This study looks at whether using a CPAP machine (commonly used for sleep apnea) can help people with autonomic failure who have high blood pressure when lying down and low blood pressure when standing. About 59 adults aged 40-80 with conditions like Parkinson's or multiple syste…

This study tests whether a personalized form of transcranial magnetic stimulation (rTMS) can improve movement and non-movement symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty adults aged 30-80 will receive 10 daily se…

This study looks at how pain and automatic body functions (like digestion and sweating) affect people with Parkinson's disease or multiple system atrophy. Researchers will track 280 participants during their usual rehabilitation to see if symptoms improve and how quality of life …

This study collects blood samples from up to 1,000 adults with PSP, CBS, or MSA and their family members to search for genes linked to these rare brain disorders. Researchers will sequence participants' DNA to find known and new genetic variants. The goal is to better understand …

This early-phase study at Massachusetts General Hospital is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. The study includes 40 people aged 50-80 with Parkinson's disease, multiple system …

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy, pure autonomic failure, or Parkinson di…

This study uses special brain scans to measure damage to nerve connections in people with Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP). Researchers will scan 36 adults aged 45-80 at the start and after 12 months to see how the damage changes over time. T…

This study follows nearly 3,000 people, including healthy volunteers and those with memory or movement problems, to track how brain diseases like Alzheimer's and Parkinson's develop over time. Researchers use advanced brain scans and tests to find early signs of disease. The goal…

This study is looking for better ways to diagnose Parkinson's disease and two similar conditions (Multiple System Atrophy and Progressive Supranuclear Palsy) using brain scans and artificial intelligence. Researchers will analyze scans from 90 adults to find patterns that can tel…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…

This study is following 600 people with Parkinson's disease and 100 with multiple system atrophy over time. Researchers are collecting medical history, biological samples, brain scans, and regular check-ups every six months. The goal is to find early signs of disease, improve dia…