MULTIPLE SYSTEM ATROPHY

This early-phase study tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The goal was to see if the vaccine is safe and helps the body make antibodies against a harmful protein linked to these brain diseases. The study focused on safe…

This study looked at whether a portable sleep test (ambulatory polygraphy) done during a short hospital stay works as well as the standard overnight sleep test (polysomnography) for finding sleep apnea in people with multiple system atrophy (MSA). Thirty adults with probable MSA …

This study tested a new type of PET scan that looks for a protein called alpha-synuclein in the brain, which is linked to Parkinson's disease, multiple system atrophy, and a sleep disorder that often leads to Parkinson's. Researchers scanned 55 people, including healthy volunteer…

This study tested a drug called droxidopa (L-threo DOPS) against a placebo in 107 people with multiple system atrophy (MSA) who had dizziness and fainting from low blood pressure when standing. The goal was to see if the drug could improve these symptoms over 3 months. Participan…

This study looked at whether a special counseling program for caregivers can improve the quality of life for both people with multiple system atrophy (MSA) and their caregivers. MSA is a rare, serious brain disease that makes daily activities very hard. The study involved 130 pat…

This study looked at two common treatments for a condition where blood pressure drops sharply when standing up (orthostatic hypotension) in people with autonomic failure. The treatments were a medication called midodrine and a tight abdominal binder. Researchers measured heart he…

This study tested a special belt that automatically tightens around the belly to help people whose blood pressure drops sharply when they stand up. 28 adults with autonomic failure (including multiple system atrophy) tried the device. The goal was to see if it safely improves sta…

This study looked at how wearing a tight abdominal binder helps people with autonomic nervous system failure who experience a sharp drop in blood pressure upon standing. Researchers measured changes in heart function and blood flow in 21 participants during head-up tilt tests. Th…

This study tested whether a 12-month education program for people with Multiple System Atrophy (MSA) and their caregivers is practical. The program included in-person visits and online activities to help them understand symptoms and cope. Only 15 patient-caregiver pairs took part…

This study looked at why people with multiple system atrophy (MSA) often feel pain. Researchers measured pain thresholds in 42 participants (MSA patients, Parkinson's patients, and healthy volunteers) using heat stimulation and reflex tests. They also checked if a Parkinson's med…