METASTATIC CANCER

This study tests whether adding a second DNA vaccine to a standard immunotherapy (pembrolizumab) can better control advanced prostate cancer that no longer responds to hormone therapy. About 60 adults with metastatic, castration-resistant prostate cancer will receive either one o…

This study tests whether the drug MGD019 can help control advanced cervical cancer that has spread or come back. About 47 people who have not yet received treatment will take part. The goal is to see if the drug improves survival.

This early-phase study tests a new investigational drug (RP-6306) combined with two standard chemotherapies (carboplatin and paclitaxel) in people with recurrent ovarian or uterine cancer that has a specific genetic change (TP53 mutation). The main goal is to find the safest dose…

This early-stage study tests a new drug that delivers radiation directly to cancer cells that make a protein called CEA. The drug, Ac225-DOTA-M5A, is designed to find and kill these cancer cells while sparing healthy tissue. The study includes up to 20 people with advanced or met…

This early-phase study tests a new drug, NTX-1088, which blocks a protein on cancer cells that helps them hide from the immune system. The trial includes about 90 adults with advanced solid tumors that have not responded to standard treatments. Participants receive NTX-1088 alone…

This study tests the drug niraparib in 20 people whose cancer has spread to the brain or spinal cord. The goal is to see if the drug can shrink or control these tumors. Participants must have mild or no symptoms from their brain metastases and not need increasing steroids or seiz…

This study enrolls healthy relatives of patients with advanced HPV-related head and neck cancer. Donors receive a therapeutic HPV vaccine to boost their immune cells against HPV. These cells are then collected and used in a separate transplant or cell infusion to treat the patien…

This study tests whether adding the experimental drug CGT9486 to the standard drug sunitinib works better than sunitinib alone for people with advanced gastrointestinal stromal tumors (GIST) that can't be removed by surgery or have spread. About 482 adults who have already tried …

This study tests a drug called RP-3500 combined with radiation therapy for people with advanced solid tumors that have spread and have a specific gene change (ATM mutation). The goal is to find a safe dose and see if the combination can control tumor growth for at least 6 months.…

This early-phase study tests whether a drug called AZD1390, given together with a precise type of radiation (SBRT), is safe for people whose solid tumors have spread to other parts of the body. About 54 adults with metastatic cancer will receive increasing doses of the drug along…

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can help restart the immune system's fight against cancer when immunotherapy drugs start to lose effect. About 69 adults with metastatic cancers (melanoma, lung, bladder, kidney, or head/neck) will re…

This study tests a drug called avelumab in 25 people with advanced penile cancer who cannot have standard chemo or whose cancer got worse after chemo. Avelumab works by blocking a protein that helps tumors hide from the immune system, which may shrink or slow the cancer. The main…

This study tests a combination of four drugs—two standard chemotherapy drugs plus two experimental ones—in people with advanced pancreatic cancer that has spread. The goal is to see if this mix is safe and can shrink tumors. About 40 adults who haven't had treatment yet will take…

This study tests whether adding ramucirumab to the standard drug osimertinib can help people with a specific type of advanced lung cancer (EGFR-mutant) live longer without their disease getting worse. About 160 adults with advanced or metastatic non-small cell lung cancer that ha…

This study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. It involves 3 adults with newly diagnosed advanced or metastatic pancreatic cancer. The goal is to see if…

This study looks at whether giving focused, high-dose radiation (SABR) to a small number of growing cancer spots can help people with advanced lung cancer stay stable longer. About 90 adults with non-small cell lung cancer that has spread and is growing in just a few places will …

This study tests a drug called adagrasib (MRTX849) in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe, how the body processes it, and whether it can shrink tumors. About 731 participants with various cancers (e.g.,…

This study tests a new approach for people with cancer that has spread to the bone. Participants receive a precise, high-dose radiation treatment (SBRT) followed by surgery within one week to stabilize the bone. The goal is to see if this combination is safe and helps prevent the…

This study tests two different doses of the targeted drug adagrasib in 200 adults with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants have already tried chemotherapy and immunotherapy. The goal is to see which dose works bett…

This study tests a combination of three drugs (pemetrexed, etrumadenant, and zimberelimab) in 10 adults with advanced bladder cancer that has a specific genetic change called MTAP deficiency. All participants had prior immunotherapy. The goal is to see if the combo shrinks tumors…

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This study tests whether an 8-week digital health program called COBRA is safe and practical for older adults with cancer. The program focuses on balance and resistance exercises. Researchers will track how many participants stick with the program to see if it's a feasible option…

This study looks at whether involving a radiation specialist early in care can improve quality of life for adults with metastatic cancer that cannot be cured. About 156 participants will either get standard cancer care alone or standard care plus early radiation oncology visits. …

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study collects white blood cells and tumor samples from up to 7,000 cancer patients and healthy volunteers. The cells are used in the lab to grow large numbers of immune cells that may one day be given back to patients as experimental treatments. Participants do not receive …

This study looks at how certain cancers (head and neck, esophagus, and anal canal) change at the genetic and immune level when patients receive chemotherapy or immunotherapy. Researchers collect blood and tumor samples before and during treatment to track these changes. The goal …

This study looks at tumor and blood samples from 180 people with metastatic cancer who have been treated with the drug trastuzumab deruxtecan (T-DXd). Researchers want to find a specific genetic marker that can predict how well a person will respond to the drug. The goal is to be…

This study looks for clues in the blood that might help doctors predict which cancer patients will have serious side effects from immunotherapy drugs. Researchers are comparing patients who get immunotherapy with those who get standard chemotherapy. The goal is to find markers th…

This study looks at whether a detailed genetic analysis of a patient's tumor (from a biopsy or blood sample) can help doctors pick a more effective treatment. It involves 235 adults with advanced solid cancers that have stopped responding to standard therapies. Researchers will c…

This study aimed to review past patient records to understand how well radioembolization works for liver tumors, including intrahepatic cholangiocarcinoma and metastatic liver cancer. The goal was to learn about survival and tumor recurrence. However, the study was withdrawn befo…