METASTATIC CANCER

This study is testing a new treatment sequence for patients with cancer that has spread to their bones and requires surgery to prevent fractures. Researchers want to see if giving a very precise, high-dose radiation treatment (SBRT) less than a week before the stabilizing surgery…

This trial is testing whether using highly focused, high-dose radiation on a few spots where cancer has started to spread can help delay the disease from getting worse. It compares this approach to continuing standard drug treatments alone in patients whose cancer was previously …

This study is testing whether a new oral drug called RP-3500 is safe and effective when given alongside targeted radiation therapy to people with advanced, spreading cancer that has a specific genetic change (ATM mutation). The goal is to better control the growth of tumors that …

This study is testing a special vaccine in healthy relatives of people with advanced HPV-linked cancer. The goal is to see if the vaccine safely boosts the donor's immune cells against HPV. Those immune cells are then collected and given to their sick relative in a separate treat…

This study is testing if adding a drug called ramucirumab to a standard targeted therapy (osimertinib) works better for controlling advanced lung cancer with a specific genetic change (EGFR mutation). It will involve about 160 adults who have not yet taken this type of targeted d…

This study is testing whether the immunotherapy drug avelumab can help men with advanced penile cancer that has spread or cannot be removed by surgery. It is for patients who are not suitable for standard platinum-based chemotherapy or whose cancer has continued to grow despite t…

This early-stage study is testing a new cell therapy called PD-L1 t-haNK in adults with advanced solid cancers that have spread or can't be surgically removed. The main goals are to find the safest dose and check for side effects in a small group of 16 participants who have alrea…

This trial is testing an experimental pill called MRTX849 (adagrasib) for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The study aims to find safe doses, see how the drug works in the body, and measure if it shrinks tumors. It includes 7…

This early-stage study is testing whether adding an experimental drug called RP-6306 to standard chemotherapy (carboplatin and paclitaxel) is safe for patients with recurrent ovarian or uterine cancer that has a specific genetic change (TP53 mutation). The main goal is to find th…

This early-stage study is testing whether adding three common cholesterol-lowering drugs to standard chemotherapy is safe and feasible for people with advanced pancreatic cancer. The idea is that by drastically lowering the body's cholesterol, the drugs might 'starve' the fast-gr…

This study is testing a new combination of four drugs for people with metastatic pancreatic cancer who have not yet received any treatment. The main goals are to find the safest and most effective dose of the new drug pair (avutometinib and defactinib) when added to two standard …

This study is testing whether adding a second DNA vaccine to an immunotherapy drug helps control advanced prostate cancer better than using one vaccine with the drug. It involves men whose cancer has spread and stopped responding to standard hormone-blocking treatments. The goal …

This study is testing whether the drug niraparib can help control cancer that has spread to the brain or spinal cord. It will involve about 20 adults whose cancer has specific genetic changes and has progressed despite other treatments. Participants will take the oral medication …

This study is testing if a short, high-precision form of radiation (SBRT) can help restart the effectiveness of immunotherapy drugs in patients whose cancer has started to grow again. It involves adults with certain advanced cancers (like melanoma, lung, or bladder cancer) who ar…

This large, late-stage study is testing whether adding a new drug called CGT9486 to an existing cancer drug (sunitinib) works better than sunitinib alone for people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The study wi…

This study is testing a combination of three drugs for people with advanced bladder cancer that has a specific genetic flaw called MTAP deficiency and has stopped responding to standard immunotherapy. The goal is to see if this new combination is safe and can help control the can…

This study is testing a new radioactive imaging agent to see if it can help find cancers that produce a specific protein called CEA. Twenty patients with various CEA-positive cancers will receive the agent and undergo PET scans to see if it highlights their tumors. The goal is to…

This study is testing a phone-based support program designed to help patients with advanced cancer and their family caregivers. The program focuses on improving communication, managing difficult emotions, and reducing caregiver stress. It offers a culturally tailored version for …

This study is testing if meeting with a radiation oncology specialist early in treatment, in addition to standard cancer care, improves patients' quality of life after six months. It will involve about 156 adults with cancer that has spread and is not curable, who are expected to…

This study aimed to look back at the medical records of patients with a specific type of liver cancer (intrahepatic cholangiocarcinoma) who were treated with a procedure called radioembolization. The goal was to understand the outcomes, risks, and benefits of this treatment by co…

This study aims to understand how certain advanced cancers change during treatment. Researchers will collect blood and tumor samples from 39 patients with specific types of recurrent or metastatic squamous cell cancers (head/neck, esophagus, anal canal) who are starting chemother…

This study aims to understand why some patients respond better than others to the cancer drug trastuzumab deruxtecan. Researchers will analyze tumor and blood samples from 180 patients with metastatic cancer who have received this treatment. The goal is to find biological markers…

This study is testing whether analyzing the genetic makeup of advanced cancers from blood or tissue samples helps doctors select more effective treatments. It involves 235 patients whose cancer has progressed despite standard therapies. Researchers will track if treatments chosen…

This study aims to find signs in the blood that might predict which cancer patients will experience serious side effects from a newer type of drug called immune checkpoint inhibitors. It involves 69 adults with metastatic cancer who are starting either this immunotherapy or stand…

This study collects blood and tumor cells from cancer patients and blood from healthy volunteers. The cells are used in the lab to support research into future immune cell therapies for cancers like melanoma, breast cancer, and lung cancer. No treatment is given in this study; it…