METASTATIC CANCER

This study tested a combination of two drugs, denosumab and enzalutamide, in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could delay cancer growth better than historical results w…

This study tested an experimental drug called BT-001, injected directly into tumors, either alone or with the immunotherapy pembrolizumab, in people with advanced solid tumors (like melanoma, lung, or breast cancer). The goal was to see if it was safe and could shrink tumors. The…

This study tested a new drug called OC-001, either by itself or combined with avelumab (an immunotherapy), in people with advanced cancers that had spread. The goal was to check safety and how the drug moves through the body. The trial was stopped early, and only 73 people were e…

This study tested an experimental drug called ART0380 in 36 people with advanced or metastatic solid tumors, including endometrial cancer. The goal was to see if the drug could shrink tumors. The trial was terminated early, so results are limited. Participants had to have finishe…

This early-phase study tested a gene therapy for people with metastatic cancer that has a protein called CEA. Researchers took patients' own immune cells, added a new gene to help them attack cancer, and gave them back after chemotherapy. Only 3 people took part before the study …

This study tested a combination of two drugs, futibatinib and pembrolizumab, in people with a hard-to-treat type of uterine cancer that had spread. The goal was to see if the combination could shrink tumors or slow the cancer's growth. Only 9 people took part before the study was…

This study tested the drug niraparib in 22 adults with advanced solid tumors (like breast, lung, or pancreatic cancer) that have a specific genetic change called a PALB2 mutation. The goal was to see if niraparib could shrink tumors or slow their growth. The study was stopped ear…

This early-stage study tested an experimental virus therapy called VAXINIA (CF33-hNIS) in 66 adults with advanced solid tumors that had spread. The virus was given either directly into tumors or through a vein, alone or with the immunotherapy drug pembrolizumab. The main goal was…

This early-stage study tested a new drug called DS-9606a in 88 adults with advanced solid tumors that have a specific protein (Claudin-6). The main goal was to check safety and find the right dose. The study was terminated, so results are limited.

This study tested a combination of three drugs (azacitidine, pembrolizumab, and epacadostat) in people with advanced solid tumors, including lung and colorectal cancers that had stopped responding to standard treatments. The goal was to see if the combination was safe and could s…

This early-stage study tested a new drug, BGB-B3227, alone or with another drug (tislelizumab) in 35 people with advanced solid tumors. The goal was to check safety and find the right dose. The study was terminated early, so results are limited.