Experimental virus therapy VAXINIA tested in advanced cancer patients
NCT ID NCT05346484
First seen Jan 10, 2026 · Last updated Jun 12, 2026 · Updated 16 times
Summary
This early-stage study tested a new treatment called VAXINIA (CF33-hNIS), a virus designed to attack cancer cells, in 66 adults with advanced solid tumors that had spread. The treatment was given alone or with the immunotherapy drug pembrolizumab, either as a shot into the tumor or through a vein. The main goal was to check safety and find the best dose, but the study was stopped early.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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City of Hope Medical Center
Duarte, California, 91010, United States
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Corewell Health
Grand Rapids, Michigan, 49503, United States
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Highlands Oncology
Springdale, Arkansas, 72762, United States
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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NEXT Oncology
Fairfax, Virginia, 22031, United States
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St. Vincent's Hospital
Fitzroy, Victoria, 3065, Australia
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Tasman Oncology Research
Southport, Queensland, 4215, Australia
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UC San Diego Moores Cancer Center
La Jolla, California, 92093-0698, United States
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University of Arizona Cancer Center
Tucson, Arizona, 85724-5024, United States
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University of Cincinnati
Cincinnati, Ohio, 45219, United States
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University of Miami
Miami, Florida, 33136, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.