MAJOR DEPRESSION

This study tests a new tool that combines a blood test with a questionnaire to help doctors correctly identify bipolar disorder in people who are currently depressed. About 623 adults with depression will give a blood sample and fill out forms. The goal is to see if this tool can…

This study is testing whether a stronger version of a safe, non-invasive brain stimulation technique called tDCS can help people with depression. About 20 adults with major depression will receive mild electrical pulses through electrodes on their scalp. The goal is to see if hig…

This study looks at whether breathing and aerobic exercises can affect certain brain and inflammation markers in people with major depression. Researchers will measure substances linked to nerve health and inflammation in 40 adults aged 18 to 40. The goal is to understand how exe…

This study tests whether a personalized, algorithm-based psychotherapy is more effective than usual one-on-one therapy for adults with major depression complicated by personality problems or past trauma. About 150 people in Chile's public mental health system will be randomly ass…

This study follows 1,000 adults with hard-to-treat depression or OCD who receive advanced treatments like brain stimulation or ketamine. Researchers will collect data from brain scans, cognitive tests, and voice recordings to find markers that predict which treatment works best f…

This study aims to understand how a non-invasive brain stimulation technique called continuous theta-burst stimulation (cTBS) affects brain activity in people with major depression. Researchers will give participants a single dose of different FDA-approved medications that boost …

This study looks at how sleep inertia—the grogginess you feel right after waking up—affects attention in people with major depression. Researchers will compare three groups: depressed patients with sleep inertia, depressed patients without it, and healthy controls. Participants w…

This study looks at how depression in older adults may speed up memory and thinking problems. Researchers will follow 120 people with late-life depression for 30 months, using brain scans and memory tests. The goal is to understand the link between depression and conditions like …

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study is looking for genetic markers that may predict which children and youth (ages 6-24) with depression, anxiety, or OCD will experience behavioral activation—a side effect of SSRI antidepressants like Prozac or Zoloft. Researchers will compare the DNA of 160 participants…

This study looks at why a single low dose of ketamine helps some people with hard-to-treat depression more than others. Researchers think a family history of alcohol problems may make the drug work better. They will use powerful brain scans to measure changes in brain chemicals a…

This study looks at how ketamine, a fast-acting antidepressant, works in the brain. Researchers want to see if blocking a specific receptor (AMPA) changes ketamine's effects. About 70 adults with treatment-resistant depression will stay at the clinic for 5 weeks, receive ketamine…

This study watches how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or migraines, as well as healthy volunteers. Over two years, participants wear activity trackers and light sensors, answer daily mood questions on…