Major depression
Clinical trials for Major depression explained in plain language.
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Can a brain stimulation cocktail supercharge depression treatment?
Disease control Not yet recruitingThis early-stage trial is testing whether combining a type of brain stimulation called TMS with two medications—D-cycloserine and lurasidone—can improve symptoms in adults with moderate to severe depression. Participants will receive the combined treatment and be monitored for si…
Matched conditions: MAJOR DEPRESSION
Early phase 1 • Sponsor: Mclean Hospital • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Brain scans may guide psychedelics and magnetic pulses to quell suicidal thoughts
Disease control Not yet recruitingThis trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulatio…
Matched conditions: MAJOR DEPRESSION
Phase 2 • Sponsor: University of New Mexico • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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Can virtual reality lift teen depression?
Symptom relief Not yet recruitingResearchers are testing whether an 8-week program that combines virtual reality experiences with educational lessons can help teenagers with major depression. The study will measure changes in depression and anxiety scores using standard questionnaires. Ten adolescents will parti…
Matched conditions: MAJOR DEPRESSION
Sponsor: Edward Via Virginia College of Osteopathic Medicine • Aim: Symptom relief
Last updated Sep 10, 2026 00:00 UTC
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Quick trip? LSD plus risperidone tested for depression
Symptom relief Not yet recruitingThis early-phase study tests whether a shortened LSD experience, combined with the drug risperidone, can safely ease symptoms of major depression. Ten adults with moderate to severe depression will receive LSD followed by risperidone 45 minutes later. Researchers will monitor saf…
Matched conditions: MAJOR DEPRESSION
Phase 1 • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jul 26, 2026 00:00 UTC
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Can anesthesia hide the trip? new study tests psilocybin for depression without the psychedelic experience
Symptom relief Not yet recruitingThis study tests whether giving psilocybin—a psychedelic drug being studied for depression—under general anesthesia can hide its mind-altering effects. That would allow researchers to run a truly blinded trial where neither patients nor doctors know who got the real drug. Ten adu…
Matched conditions: MAJOR DEPRESSION
Phase 2 • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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What can patients who tried both brain-stimulation treatments teach us?
Knowledge-focused Not yet recruitingThis study interviews adults who have received both electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) for major depression. Researchers want to understand how patients make sense of these treatments and how they fit into their recovery. Participants shar…
Matched conditions: MAJOR DEPRESSION
Sponsor: University of Nottingham • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Scientists probe Brain's wiring to supercharge depression therapy
Knowledge-focused Not yet recruitingThis study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…
Matched conditions: MAJOR DEPRESSION
Phase 1/2 • Sponsor: Mclean Hospital • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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Blood test clues for mental health disorders?
Knowledge-focused Not yet recruitingThis study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…
Matched conditions: MAJOR DEPRESSION
Sponsor: Carmen Concerto • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC