MAJOR DEPRESSION
Clinical trials for MAJOR DEPRESSION explained in plain language.
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Scientists try to tame a psychedelic trip to fight depression
Disease control Not yet recruitingThis early-stage study is testing whether a drug called risperidone can safely shorten the effects of LSD, and if this brief psychedelic experience might help people with moderate to severe depression. Researchers will give 10 participants LSD, followed by risperidone 45 minutes …
Matched conditions: MAJOR DEPRESSION
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Apr 03, 2026 21:26 UTC
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Sleeping through the trip: scientists test psilocybin under anesthesia for depression
Disease control Not yet recruitingThis study is testing a new method to improve research on psilocybin, a psychedelic compound, for treating major depression. To make the study more scientifically rigorous, participants will receive psilocybin or a placebo while under general anesthesia, so they won't know which …
Matched conditions: MAJOR DEPRESSION
Phase: PHASE2 • Sponsor: Stanford University • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Chile tests Smartphone-Guided therapy for tough depression cases
Disease control Not yet recruitingThis study tests whether a personalized, step-by-step therapy approach works better than standard therapy for adults with depression that is complicated by long-standing emotional and relationship difficulties, often linked to past trauma. Researchers will compare the new approac…
Matched conditions: MAJOR DEPRESSION
Phase: NA • Sponsor: Pontificia Universidad Catolica de Chile • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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VA launches major trial: psychedelic mushroom therapy for Veterans' depression
Disease control Not yet recruitingThis study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychological support, can help veterans with severe depression that hasn't improved with standard treatments. The trial will include 240 U.S. military veterans, some of whom also ha…
Matched conditions: MAJOR DEPRESSION
Phase: PHASE3 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Mar 23, 2026 15:15 UTC