MAJOR DEPRESSION

This study tested two non-invasive brain stimulation methods—high-frequency rTMS and theta-burst stimulation—in 108 adults with major depression. Participants received 10 sessions over two weeks. Both treatments reduced depressive and anxiety symptoms, with no major difference be…

This study tested a new, non-invasive brain stimulation called transcranial pulse stimulation (TPS) for people with major depression. 80 adults received either real TPS or a sham treatment over six weeks. The goal was to see if TPS can safely reduce depressive symptoms, offering …

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques—sticky proteins linked to Alzheimer's. Researchers used a special PET scan to compare plaque levels in people whose depression got better, partly better, or didn't im…

This study tested a new automated phone system called 'My Coach Connect' for people with chronic mental illness, including depression, schizophrenia, and bipolar disorder. Participants called the system twice a week to answer questions about how they were doing, and their respons…

This study tested whether giving a gentle magnetic pulse to the brain during sleep is safe and could boost depression treatment. Fifteen adults with major depression who hadn't improved with medication took part. Researchers measured brain activity and thinking skills before and …

This study tested a new way to personalize brain stimulation for depression by using heart rate responses to guide treatment. Researchers mapped the brain's frontal region in 34 healthy volunteers and people with depression, autonomic issues, and stomach discomfort. They compared…

This study looked at whether brain wave patterns (EEG) can show early on if an antidepressant is working. Thirty-eight adults with major depression took part. The goal was to see if changes in brain activity happen before mood improves, which could help doctors choose the right t…