LYNCH SYNDROME

This trial tests a vaccine called Nous-209 in 45 people with Lynch syndrome, an inherited condition that raises the risk of colorectal and other cancers. The vaccine is designed to train the immune system to recognize and attack abnormal cells that could become cancer. The study …

This study tests a drug called pembrolizumab in children whose brain tumors have come back or not responded to treatment. The drug helps the body's immune system fight cancer cells. The goal is to find the safest dose and see if it can shrink tumors in children with several types…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy helps prevent cancer from returning in people with stage III colon cancer that has a specific DNA repair problem (dMMR). About 712 participants received either chemotherapy alone or chemo…

This study was designed to test two immunotherapy drugs, nivolumab and ipilimumab, in children and young adults with cancers that returned or didn't respond to treatment and have many genetic mutations. The goal was to see if the combination could shrink tumors or help patients l…

This study tests whether a combination of two experimental drugs (Tri-Ad5 vaccine and N-803) can prevent colon cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine trains the immune system to recognize and destroy precancerous cells, whil…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which program works best to improve waist size and overall health, whi…

This study tests a weight management and health behavior program for people with BRCA+ or Lynch syndrome mutations, as well as their family members. The goal is to help participants lose weight, eat more fruits and vegetables, and be more active to lower their cancer risk. The pr…

This study tests a program to help 200 adults with hereditary cancer syndromes (like BRCA or Lynch syndrome) living in rural areas follow cancer prevention and screening guidelines. Participants get personalized care plans and regular check-ins over two years. The goal is to see …

This study looks at whether people with Lynch Syndrome, a condition that raises the risk for several cancers, follow recommended screening guidelines after genetic counseling. Researchers will track up to 1,530 participants to see how well they stick to multi-organ screening and …

This study looks at how the natural bacteria in the gut and diet might influence the risk of colorectal cancer in people with Lynch syndrome or other inherited colon polyp conditions. Researchers collect stool samples, colon tissue, and diet/lifestyle questionnaires from 77 parti…

This study looks at whether providing easy-to-understand information can help relatives of people with Lynch syndrome decide whether to get genetic counseling or testing. About 185 adult family members will be randomly given either a standard letter or a letter plus a booklet. Re…

This study tests a program called IGNITE-TX that uses a website and a genetic family navigator to help relatives of people with hereditary cancer get free genetic counseling and testing. It involves 205 adults who have a known cancer gene mutation and their at-risk family members…

This study is creating a secure database of 317 patients at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. The goal is to find better ways to detect the disease early or even prevent it. No new treatments are being tested; i…