LYNCH SYNDROME

This large study is testing if adding a drug called atezolizumab, which helps the body's immune system fight cancer, to standard chemotherapy works better than chemotherapy alone. It's for patients with stage III colon cancer that has been surgically removed but has a high risk o…

This early-phase study aimed to test the safety and find the right dose of a two-drug immunotherapy (nivolumab and ipilimumab) for children, teens, and young adults whose cancers had returned or stopped responding to standard treatments. The drugs work by helping the patient's ow…

This early-stage trial is testing the safety and early effectiveness of a drug called pembrolizumab in children with aggressive brain tumors that have come back or stopped responding to standard treatments. The drug is an immunotherapy, which aims to help the body's own immune sy…

This study is testing different combinations of lifestyle coaching methods to help people with BRCA or Lynch syndrome gene mutations lose weight and maintain healthy habits. Researchers want to find the most effective and affordable mix of support—like phone calls, emails, text m…

This study is testing a new support program for adults who have inherited gene changes that increase their cancer risk, especially those living in rural areas. The program provides personalized care plans and regular check-ins over two years to help participants follow recommende…

This study is testing different ways to help people at high risk for cancer or cancer survivors become more active and eat healthier foods. Researchers are comparing methods like weekly phone calls, emails, daily text messages, and online forums to see which combinations work bes…

This trial is testing a vaccine called Nous-209 in people with Lynch syndrome, a genetic condition that greatly increases the risk of colorectal and other cancers. The vaccine is designed to teach the body's immune system to recognize and attack early cancer cells. Researchers wa…

This study is testing whether a combination of a three-part vaccine and an immune system booster can prevent colon and other cancers in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. The vaccine aims to train the body's immune system to recogn…

This study is testing two different ways to share genetic test results related to breast cancer risk with African American women. Researchers want to see if an online, self-guided program works as well as the standard method of a phone call with a genetic counselor. The goal is t…

This study is testing whether educational materials help relatives of people with Lynch syndrome decide about getting genetic counseling and testing. About 185 relatives at risk will receive either a standard information letter or the letter plus an educational booklet. Researche…

This study aims to create a large database of patient information to find better ways to detect pancreatic cancer early, when it's most treatable. It involves 317 adults at Moffitt Cancer Center who have pancreatic cysts, a strong family history of pancreatic cancer, or other ris…

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study aims to understand if the bacteria living in our gut and our diet affect cancer risk in people with inherited conditions that make them prone to colon cancer. Researchers are collecting stool samples, colon tissue from routine colonoscopies, and diet questionnaires fro…

This study aims to understand if people with Lynch Syndrome, a genetic condition that increases cancer risk, follow through with the recommended screening tests for multiple organs after receiving genetic counseling. Researchers are observing over 1,500 adults who have received t…