LYNCH SYNDROME

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without sedation. About 30 adults who are healthy or have Lynch syndrome, Crohn disease, or inflammatory bowel disease will try it. The goal is to see if the capsule can get clear imag…

This study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, precancerous polyps, and Lynch syndrome-related cancers early. Researchers will collect blood from 1,200 people who have already had a colonoscopy and see how accurate the test is…

This study tests if a menstrual cup can collect enough uterine tissue to screen for endometrial cancer in women with Lynch syndrome, who have a higher risk. Participants will use a menstrual cup at home and also have a standard biopsy, then compare the samples. If it works, this …

This study is testing whether a urine test that looks for tumor DNA can find bladder and urinary tract cancers early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 200 participants aged 50–75 will provide urine samples and be followed for one ye…

This early-stage trial tests a personalized vaccine made from a person's own immune cells to prevent cancer in adults with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine is designed to train the immune system to recognize and attack cells with specific p…

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises colon cancer risk. About 40 participants will take either naproxen, aspirin, or a placebo for a short time. Researc…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500 …

This study compares an artificial intelligence system (CAD-EYE) to the standard dye-spray method for finding precancerous growths during colonoscopy in people with Lynch syndrome, a genetic condition that raises colon cancer risk. About 272 adults with confirmed Lynch syndrome wi…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at whether people with Lynch syndrome can collect their own vaginal samples at home to check for early signs of uterine cancer. About 30 participants will use a self-collection kit and answer surveys. The goal is to see if this method is practical and acceptable,…

This study is screening 9,000 people at high risk for pancreas cancer to find early warning signs. Participants include those with strong family history or certain genetic mutations. Researchers will analyze pancreatic juice and cyst fluid to detect cancer markers before the dise…

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…

This study looks at how the immune system's surveillance affects the development of colorectal cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will follow 300 participants with Lynch syndrome who are already undergoing regular cancer…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a camera in a pill) to screen for early growths or cancer. The goal is to see how well this test finds precancerous or cancerous lesions in the small bowel. Results …

This study looks at how well a tiny camera you swallow (videocapsule endoscopy) can find early signs of small bowel cancer in people with Lynch syndrome. About 100 adults with Lynch syndrome will swallow the camera pill as part of their regular care. Researchers will track how ma…