IDIOPATHIC PULMONARY FIBROSIS

This study tested an inhaled medication called treprostinil in 598 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The goal was to see if the drug could slow the decline in lung function over one year compared to a placebo…

This study tested an experimental tablet called HSK44459 in 186 adults aged 40 and older with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. The main goal was to see if the drug improves lung function measured by a breathing tes…

This study tested an oral drug called GRI-0621 in 35 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. The main goal was to check safety and how the drug affects certain biomarkers in the blood. Participants took either t…

This early study tested a single injection of stem cells from donated umbilical cords in 17 people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal was to see if the treatment is safe and tolerable, and to find the b…

This study tested an experimental drug called PLN-74809 in 10 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. Participants took the drug or a placebo daily for 12 weeks. The main goal was to see if the drug could reduce collagen b…

This study tested three different doses of an experimental oral medicine, BI 1819479, against a placebo in 322 adults aged 40 and older with idiopathic pulmonary fibrosis (IPF). The goal was to see if the drug could slow the decline in lung function, measured by breathing tests, …

This early-stage study tested an inhaled drug called ARO-MMP7 in 105 people, including healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal was to check safety and how the drug moves through the body. Researchers also me…

This study tested a drug called MN-001 in 15 people with moderate to severe idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. Participants took either MN-001 or a placebo twice daily for 6 months, followed by an open-label phase wher…

This study tested a new medicine called BI 1015550 in over 1,100 adults with idiopathic pulmonary fibrosis (IPF), a serious lung disease. Participants took either the study drug or a placebo twice daily for up to 2.5 years. The main goal was to see if the drug slowed the decline …

This early-stage study tested a new medicine called BI 1015550 in 15 people with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. The main goal was to see if the drug is safe and tolerable when taken by mouth for up to 12 weeks. Res…

This study tested a daily pill called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. The main goal was to see if the drug is safe and tolerable over 12 weeks. Researchers also measured how the drug moves…

This study tested whether the drug N-acetylcysteine (NAC) could help people with a specific genetic type of idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 202 adults with the TOLLIP TT gene received either NAC or a placebo alongside their usual care. The goal …

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing difficult. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Resear…

This early-stage study tested a new drug called HuL001 in 24 people, including healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. The main goal was to check if the drug is safe and how the body processes it. Researchers monitored si…

This study tested a cell therapy called REGEND001 for people with idiopathic pulmonary fibrosis (IPF), a serious lung-scarring disease. 23 adults received either the cell treatment or a placebo to see if it could improve lung function. The therapy uses special lung cells that may…

This study tested whether low-dose morphine can reduce coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. About 44 adults with chronic cough took either morphine or a placebo for 14 days, then switched. The goal was to see if morphine safely les…

This study followed 18 adults with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who had diarrhea after starting the drug nintedanib. The goal was to see how many could control their diarrhea (fewer than 3 loose stools per day) after 12 weeks while stayin…

This study tested the safety of a purified green tea extract called EGCG in 50 people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. Participants took EGCG or a placebo daily for 12 weeks. The main goal was to see if EGCG is safe and how it interacts with stand…

This study looked at whether breathing 60% oxygen during an 8-week exercise program helps people with idiopathic pulmonary fibrosis (IPF) who are taking nintedanib. 78 adults with IPF took part. Researchers measured how long they could exercise on a bike and how far they could wa…

This study tested a drug called orvepitant to see if it can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. 80 adults with IPF and a persistent cough participated. The study compared orvepitant to a placebo to measure changes i…

This study looked at whether lung MRI could be used instead of CT scans to diagnose idiopathic pulmonary fibrosis (IPF), a serious lung disease. Researchers compared MRI images to standard CT scans in 60 adults to see if MRI could spot the same key signs of lung scarring. The goa…

This small study looked at whether a device that delivers gentle thumps to the lungs (intrapulmonary percussion ventilation) can help inhaled medication reach scarred areas in people with idiopathic pulmonary fibrosis (IPF). Nine adults with IPF took part. Researchers measured ho…

This study looked at 178 people with advanced cancer, chronic kidney disease, or chronic lung disease to find out when they need palliative care. Researchers used special scores to see if care was given at the right time. No extra treatments or visits were added—just observation …

This study tested whether a special PET scan can detect changes in lung collagen (scar tissue) in people with idiopathic pulmonary fibrosis (IPF) after taking a green tea extract called EGCG. Twelve participants from a larger EGCG study received the PET scan before and after trea…

This study looked at how a new medicine called HEC585 interacts with two existing drugs (pirfenidone and nintedanib) used for idiopathic pulmonary fibrosis (IPF), a serious lung disease. Thirty-three healthy adults took part to measure drug levels and check for side effects. The …

This completed study looked at over 10,000 people in France who were prescribed antifibrotic drugs for idiopathic pulmonary fibrosis (a serious lung disease). The goal was to see how many patients continued their treatment for up to 30 months and what factors might cause them to …