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Can a puff of oxygen during exercise ease breathlessness for IPF patients?

NCT ID NCT03688334

Symptom relief Sponsor: George Papanicolaou Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving extra oxygen (40%) during exercise helps people with idiopathic pulmonary fibrosis (IPF) who do not have low oxygen at rest but do get low oxygen when active. Fifteen stable IPF patients completed exercise tests while breathing either oxygen or medical air (sham). The researchers measured exercise duration, breathlessness, fatigue, and oxygen levels in the brain and muscles.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oxygen supplementation (40%)
What this could lead to
If it works, this could show that using oxygen during exercise helps people with IPF feel less breathless and exercise longer.
What could go wrong
This is a very small, early study with only 15 people. The results may not apply to all IPF patients, and the benefit may be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

15 people

The number who actually took part.

Started

Jun 2018

Finished

Jun 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stable IPF patients with no hospitalization, exacerbation or change in regular IPF medication during the last month * IPF patients do not present with resting hypoxemia, but manifest exercise induced hypoxemia Exclusion Criteria: 1. Major contraindications for CPET conduction 2. Not provision of informed consent -

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic pulmonary fibrosis

Contacts and locations

Locations

  • "G. Papanikolaou" General Hospital

    Thessaloniki, 57010, Greece

More trials for these conditions

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