HYPERCHOLESTEROLEMIA

This Phase 3 study tested whether adding an investigational drug called MK-0616 (enlicitide) to standard statin therapy could better lower 'bad' LDL cholesterol in adults with a genetic form of high cholesterol. Over 300 participants were randomly assigned to receive either the d…

This completed Phase 3 study tested whether a new drug called MK-0616 works better than existing cholesterol medications at lowering 'bad' LDL cholesterol. The trial involved 301 adults with high cholesterol who were already taking statin medications. Researchers compared MK-0616…

This study observed how well a medication called Atostazet works to lower cholesterol in people 65 and older. Researchers followed 641 patients with high cholesterol for six months to see how the drug affected their cholesterol and blood sugar levels, and to check for side effect…

This study tested a new medication called K-877 (pemafibrate) for people with high cholesterol who cannot tolerate standard statin drugs due to side effects. It involved 71 adult patients who took either a low dose, a higher dose, or a placebo pill for 12 weeks. The goal was to s…

This study observed how well different cholesterol-lowering treatments work in everyday medical practice. Researchers followed 1,871 adults with high cholesterol who were starting new medications, including a newer injectable drug called inclisiran. The study collected informatio…

This large study tested whether an experimental drug called MK-0616 could safely lower 'bad' cholesterol (LDL-C) in adults with high cholesterol. Nearly 3,000 participants, who were already on standard cholesterol medications, received either the drug or a placebo for 24 weeks. T…

This study tested if a single pill combining two cholesterol-lowering drugs (ezetimibe and rosuvastatin) works better than rosuvastatin alone. It involved 305 Chinese adults whose high cholesterol was not well controlled despite already taking a statin. The main goal was to see i…

This large, completed Phase 3 trial tested whether a new drug called obicetrapib could help people with high cholesterol and heart disease who weren't getting enough benefit from their current medications. Over 2,500 participants took either the new pill or a placebo (a dummy pil…

This study tested a new injectable drug called inclisiran to see how well it lowers 'bad' cholesterol (LDL-C) in people with high cholesterol who were not taking any other cholesterol medications. It involved 350 adults and directly compared inclisiran's effects to both a placebo…

This small study tested whether eating a daily portion of sunflower seeds could help lower high cholesterol. Researchers recruited 28 middle-aged men with elevated cholesterol and had half of them eat the seeds for 45 days. The goal was to see if this simple, natural food could b…

This study directly compared two cholesterol-lowering medications—Inclisiran (given as two injections) and Bempedoic Acid (taken as a daily pill)—in 402 adults with heart disease who still had high cholesterol despite taking maximum statin therapy. The goal was to see which drug …

This study observed what happens when patients with high cholesterol switch from taking just a statin medication to taking a combination of two cholesterol-lowering drugs (pitavastatin and ezetimibe). It followed nearly 7,000 adults for 24 weeks to see if the combination was more…

This study looked at whether a supplement called red yeast rice helps lower high cholesterol in men and reduces their future risk of heart disease. Researchers followed 41 men aged 35-55 who took the supplement for up to two years. They checked cholesterol levels and also collect…

This study tested whether a new combination pill containing two drugs (obicetrapib and ezetimibe) could lower 'bad' cholesterol (LDL-C) more effectively than a placebo or either drug alone. It involved 407 adults with a genetic cholesterol disorder (HeFH) or established heart dis…

This study looked at how well the cholesterol-lowering drug Livalozet works and how safe it is for people with high cholesterol. It specifically compared results between patients who also have diabetes and those who do not. Researchers observed over 1,500 patients for 24 weeks to…

This study aimed to understand how fat particles called lipoproteins move through the body in healthy people and in people with high cholesterol or other blood fat disorders. Researchers tracked these particles using tiny, safe amounts of radioactive material injected into 759 pa…

This study looked back at the health records of nearly 12,000 adults in China with high cholesterol. Researchers wanted to see how well two newer types of injectable cholesterol medicines worked for people in everyday life, outside of a controlled trial. They compared the effecti…