HYPERCHOLESTEROLEMIA

This study tested two drugs—inclisiran (a shot) and bempedoic acid (a pill)—in 402 adults with heart disease and high LDL cholesterol despite taking statins. The goal was to see which drug lowers cholesterol more effectively. Participants were already on maximum statin therapy, a…

This study looked at whether eating sunflower seeds every day can help lower cholesterol in adults with high cholesterol. 28 men aged 40-50 with high cholesterol ate a set amount of sunflower seeds for 45 days. Their cholesterol levels were measured before and after to see if the…

This study tested a new medication called MK-0616 in 303 adults with a genetic condition that causes very high cholesterol (heterozygous familial hypercholesterolemia). Participants took either the drug or a placebo, and researchers measured how much their bad cholesterol (LDL-C)…

This study looked at how well two types of cholesterol-lowering drugs (inclisiran and PCSK9 mAbs) work in everyday medical practice in China. Researchers analyzed health records from over 11,000 adults with high cholesterol. The goal was to see how much these drugs lower 'bad' ch…

This study looked at how a red yeast rice supplement (LipoCol Forte) affects cholesterol in 41 men aged 35–55 with high cholesterol. Researchers checked blood, gut bacteria, and bile acids over two years to see if the supplement lowers heart disease risk. The goal is to understan…

This study looked at how well the drug Livalozet lowers bad cholesterol in people with high cholesterol, comparing those who also have diabetes to those who do not. Over 1,500 adults took part for 24 weeks. The main goal was to measure the drop in LDL cholesterol levels.

This phase 3 study tested a daily pill that combines two drugs, obicetrapib and ezetimibe, in 407 adults with inherited high cholesterol or heart disease who were already on maximum cholesterol-lowering therapy. The goal was to see if the combination could further lower LDL (bad)…

This study tested a new drug called obicetrapib in over 2,500 adults with high cholesterol or heart disease whose cholesterol was not well-controlled by their current medications. Participants took either the drug or a placebo pill daily for about 6 months. The main goal was to s…

This study tested a new medicine called inclisiran in 350 adults with high cholesterol who were not taking any other cholesterol-lowering drugs. The goal was to see if inclisiran could lower 'bad' LDL cholesterol more than a placebo or another drug called ezetimibe. Participants …

This study tested whether adding inclisiran (a twice-yearly injection) to standard cholesterol-lowering therapy helps more high-risk patients reach their LDL cholesterol goals. About 1,770 adults with very high or high cardiovascular risk participated. The main goal was to see ho…

This study tested a new drug called MK-0616 (enlicitide) to see if it lowers 'bad' LDL cholesterol better than current medicines ezetimibe, bempedoic acid, or both combined. About 300 adults with high cholesterol and heart disease risk took part. The main goal was to check choles…

This study tested an experimental drug called MK-0616 in nearly 3,000 adults with high cholesterol. The goal was to see if it could safely lower 'bad' LDL cholesterol more than a placebo over 24 weeks. Participants either had a history of heart disease or were at high risk, and m…

This early-phase study tested a new supplement called BKR-017 in 9 adults already taking statins for high cholesterol. The goal was to see how the body handles the supplement and if it is safe. Participants took BKR-017 twice daily for a week, and researchers measured butyrate le…

This study looked at how a newer cholesterol-lowering drug called inclisiran (Leqvio®) and other oral medications work in real-life medical care. About 1,868 adults with high cholesterol took part, but no new treatments were given—just routine care was observed. The goal was to s…

This study looked at whether drinking Dachundou No Sugar Added Soymilk every day for 8 weeks could help lower cholesterol in adults with high cholesterol. 25 people with total cholesterol of 200 mg/dL or higher took part. Researchers measured cholesterol, blood pressure, and othe…

This study looked at whether drinking a calcium-bicarbonate mineral water called Lete can lower bad cholesterol (LDL) in healthy adults aged 18-60 with high cholesterol. 160 participants drank either Lete or a regular mineral water for 4 months. The goal was to see if the special…

This study tested a drug called pemafibrate (K-877) in 71 adults with high cholesterol who cannot take statins because of side effects. Participants took either a low or high dose of pemafibrate or a placebo for 12 weeks. The main goal was to see if the drug lowers LDL (bad) chol…

This study tested a single pill combining two cholesterol-lowering drugs (ezetimibe and rosuvastatin) against rosuvastatin alone in 305 Chinese adults whose high cholesterol was not well controlled by statins. After 8 weeks, the combo pill was more effective at lowering LDL (bad)…

This study tested whether a single pill containing three medicines (ezetimibe, rosuvastatin, and amlodipine) can safely lower both cholesterol and blood pressure in Korean adults with high blood pressure and high cholesterol. 163 participants were randomly assigned to receive eit…

This study looked at how well the drug atostazet lowers cholesterol and affects blood sugar in people aged 65 and older with high cholesterol. Over 600 participants took the drug for 6 months while researchers monitored side effects and changes in glucose metabolism. The goal was…

This study looked at adults with high cholesterol who switched from a single statin drug to a combination pill containing pitavastatin and ezetimibe. Over 6,900 participants were followed for 24 weeks to see how much their LDL (bad) cholesterol dropped. The goal was to see if the…

This study looked at how fat particles called lipoproteins travel in the blood. Researchers wanted to better understand normal and abnormal fat metabolism and its link to hardening of the arteries. About 759 healthy volunteers and people with cholesterol disorders took part. Part…