HYPERCHOLESTEROLEMIA

This study tests an experimental drug, alirocumab, given once a week to adults with high cholesterol. The goal is to see how well it lowers LDL (bad) cholesterol and what side effects may occur. About 420 participants will take part to find the best dose and check safety.

This study compares two cholesterol-lowering approaches in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate statin plus ezetimibe, the other a high-dose statin alone. The goal is to see which strategy better prevents majo…

This study compares a three-drug combination (atorvastatin, ezetimibe, and bempedoic acid) against the usual two-drug therapy for lowering LDL cholesterol in people who recently had a heart attack or unstable angina. About 120 adults will take either the triple or dual therapy fo…

This study tests a new drug called SHR-1918 for people with high cholesterol that remains high even after taking statins and another type of cholesterol-lowering drug (PCSK9 inhibitors). About 126 adults will receive either SHR-1918 or a placebo to see if it safely lowers their c…

This study tests whether a combination of three cholesterol-lowering drugs (bempedoic acid, ezetimibe, and a high-intensity statin) can shrink and stabilize plaque in the coronary arteries. It includes 103 adults with early atherosclerosis who have never had a heart attack or str…

This study tests whether combining two different cholesterol-lowering drugs (inclisiran and alirocumab) works better than either drug alone. About 60 adults with high heart risk who cannot take statins will be assigned to one of three groups and followed for 9 months. The goal is…

This small pilot study will test whether a pharmacist-led program to manage high blood pressure and high cholesterol can help protect brain health in 10 people aged 50-75 who carry the APOE ε4 gene, a known risk factor for dementia. Participants will take standard medications (AR…

This study looks at medical records from Japan to see how well patients take two different cholesterol-lowering drugs (inclisiran and evolocumab) over 12 months. It will include about 3,600 adults with high cholesterol. The goal is to understand which treatment people are more li…

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …

This study tests whether sending an electronic letter to people with ischemic heart disease and high cholesterol encourages them to get their cholesterol checked. About 100,000 adults in Denmark will either receive the letter or not, and researchers will track lab tests and docto…