HPV

This study tests if a game-based program can encourage HPV vaccination in vulnerable youth aged 11-14. Researchers will enroll 180 parent-child pairs to see if the game increases vaccine confidence and uptake. The goal is to prevent HPV-related cancers by making vaccination easie…

This early-phase trial tests a new vaccine called PANHPVAX in 45 healthy adults aged 18-45. The vaccine targets a part of the HPV virus (L2 antigen) to potentially protect against more HPV types than current vaccines. The main goal is to check safety and how the body responds to …

This study looks at whether women living with HIV can get the same protection from the HPV vaccine with 2 doses instead of the usual 3. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have never received the HPV vaccine. If 2 doses work as well, it …

This study is for people with HPV-related throat cancer who have had or will have surgery to remove the tumor. Researchers will use a blood test to look for tiny bits of cancer DNA (ctDNA) to see if the cancer is likely to come back. The goal is to find out if some patients can s…

This study tests a combination of the experimental drug volrustomig with standard chemotherapy (paclitaxel and carboplatin) in people with untreated, locally advanced HPV-negative head and neck cancer. After initial treatment, the next steps are tailored based on how well the tum…

This study tests whether a dietary supplement called Papillex® can help reverse abnormal cervical cells caused by HPV in women with mild to moderate precancerous changes (CIN 1 or 2). Sixty women will take either Papillex® or a placebo daily for 180 days. Researchers will compare…

This study is for people with early-stage HPV-related throat cancer. The standard treatment is strong radiation plus chemotherapy, which can cause long-term side effects. Researchers want to see if giving only a lower dose of radiation (without chemo) works just as well to keep t…

This study is for people with HPV-positive throat cancer. It tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) to control the cancer, while causing fewer side effects. About 121 participants will …

This study explores whether women can accurately collect their own samples to test for HPV, the virus that can cause cervical cancer. Researchers will compare results from two different self-collection kits to standard Pap smears. The goal is to make screening easier and more acc…

This study is testing whether a special menstrual pad (Q-Pad) can accurately detect high-risk HPV from period blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab. Researchers w…

This study tests whether giving nurses and staff the authority to give the HPV vaccine without a doctor's order (called standing orders) can increase vaccination rates in teens. About 16,000 patients aged 9-17 from 40 medical practices will take part. The goal is to prevent HPV-r…

This study aims to make cervical cancer screening easier for women in low-resource areas of Texas. It involves 920 women aged 25 and older who haven't had a Pap test in over 3.5 years. The approach uses community-based strategies to increase access and participation.

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or CMV. Researchers want to find out if problems in the immune system or genes are to blame. Up to 600 participants and their relatives will provide blood…

This study looks at the best ways to offer HPV self-collection kits to women who are overdue for cervical cancer screening. About 1,000 women aged 25-65 will be offered a kit to use at home or in the clinic. The goal is to see how many people complete the test and follow up on po…

This study looks at whether testing for HPV (the virus that causes cervical cancer) can help find cancer that comes back after radiation treatment. Researchers will follow 120 women for two years after their radiotherapy, using both a cervical swab and a blood test to check for H…

This study looks at whether offering a simple self-sampling test for HPV in the emergency department can help more people get screened for cervical cancer. Researchers will enroll about 200 people aged 30-65 who have a cervix and are not already at high risk. The goal is to see i…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are in this group, how well anal swabs can detect them, and how these lesions affect quality of life. About 296 pa…

This study looks at 400 women with HIV to understand how the balance of bacteria in the gut and vagina might make them more likely to get HPV and develop cervical lesions. Researchers will collect samples to track HPV infections and cervical changes over time. The goal is to lear…

This study looks at how different menstrual products—tampons, menstrual cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18 to 49 to compare the vaginal health of users of each product type. The goal is to und…

This study looks at whether it's possible to run a larger research project on surgery for a type of eye cancer (OSSN) in people living with HIV in Sub-Saharan Africa. About 84 participants will have the suspicious eye growth removed and be checked for up to a year. The goal is to…

This study is testing a mobile health tool called mSaada to help community health workers screen women for cervical cancer in western Kenya. Researchers will work with 6,000 women and health volunteers to see if the app makes screening easier and more effective. The goal is to fi…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions shrink or disappear without surgery. Researchers will compare those who are monitored closely with those who receive standard cone biopsy, tracking HPV clearance and…

This study tests whether people living with HIV can collect their own swab samples to screen for HPV, a virus that can lead to anal cancer. Researchers will compare the accuracy and comfort of self-screening versus a traditional swab done by a healthcare professional. The goal is…