GASTRIC CANCER (GC)

This study is for people with stomach cancer that has spread to the lining of the abdomen. It tests a treatment called HIPEC, where heated chemotherapy is given directly into the abdomen during surgery to remove the tumor. The goal is to see if this lowers the chance of cancer co…

This study tests whether a chemotherapy combination using oxaliplatin plus S-1 works as well as docetaxel plus S-1 for people with stage III stomach cancer who have had surgery. About 387 adults will be randomly assigned to one of the two treatments. The goal is to see which comb…

This study tests a new combination of drugs (iparomlimab and tuvonralimab, called QL1706) plus chemotherapy for people with advanced stomach or gastroesophageal junction cancer that hasn't been treated yet. The goal is to see if the combo can shrink tumors and control the disease…

This study tests a combination of two or three drugs (SHR-1701, rivoceranib, and possibly SHR-2554) in 40 adults with advanced stomach or gastroesophageal junction cancer that has worsened after or was not tolerated during first-line immunotherapy. The goal is to see if the combi…

This study tests whether adding radiation to a mix of chemotherapy and two immunotherapy drugs before surgery can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 adults with HER2-negative disease will be randomly assigned to recei…

This early-stage study tests a new drug called SH009 in about 150 people with advanced solid tumors (like liver, lung, or breast cancer) that have not responded to standard treatments. The main goal is to see if the drug is safe and can shrink tumors. Researchers will also measur…

This study tests a new type of PET scan called [¹⁸F]FAPI-74 to see if it can more accurately detect whether stomach or esophageal cancer has spread to other parts of the body. About 200 adults with these cancers will receive one dose of the imaging agent and then be scanned. The …

This study is developing a blood test that looks for tiny molecules called miRNAs to detect several types of digestive system cancers (like liver, pancreatic, and colon cancer) early. The goal is to create a simple, noninvasive screening tool that can be used for large population…

This study tests a new, dye-free way to check blood flow during gastrointestinal surgery. About 200 adults having planned gut surgery will be randomly assigned to either the new light-based method (iPPG) or the standard dye method (ICG). The goal is to see if the new method works…

This study aims to develop an artificial intelligence (AI) system that can predict how well stomach cancer will respond to chemotherapy and immunotherapy given before surgery. Researchers will collect data from 2,000 patients with locally advanced stomach cancer. If successful, t…

This study looks at different ways surgeons rebuild the digestive tract after removing the upper part of the stomach due to cancer. The goal is to find which method causes fewer problems like acid reflux, trouble swallowing, and poor nutrition, and leads to a better quality of li…

This study looks at how much of a specific lymph node area (called No.4sb) should be removed during surgery for advanced stomach cancer. Researchers will track 400 patients to see where cancer spreads in these nodes. The goal is to find the best balance between removing all cance…