FATIGUE

This pilot study tests whether taking a seaweed supplement called fucoidan for 8 to 16 weeks can reduce fatigue and inflammation in cancer survivors. Researchers will enroll 40 adults who have completed cancer treatment within the last 10 years and still feel tired. The main goal…

This study tests whether a daily supplement called APPORTAL® can reduce fatigue in breast cancer patients undergoing chemotherapy. The supplement contains a mix of vitamins, minerals, and other nutrients. 92 women will take either the supplement or a placebo for 8 weeks, alongsid…

This study looks at whether a simple, twice-weekly resistance exercise program using bands can help manage fatigue in breast cancer survivors. Researchers will enroll 60 women from different income backgrounds to see if the program is practical and who sticks with it. The goal is…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This pilot study in Singapore looks at whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue in female breast cancer patients. About 100 women who have completed surgery and chemotherapy will try these approaches. The goal is to see if these treatment…

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This study aims to find out if combining counseling and education with an open-label placebo (a pill that patients know has no active drug) can improve quality of life for people with advanced cancer who suffer from fatigue. About 240 adults with metastatic cancer and significant…

This study looks at whether a type of talking therapy (cognitive behavioral therapy) can help reduce severe fatigue in primary care patients. About 190 adults aged 18-67 with long-lasting fatigue will either get the therapy or usual care. The goal is to see if the therapy improve…

This study tests whether a gentle magnetic pulse to a specific brain area can reduce fatigue in people with multiple sclerosis. Sixty participants will receive either real or fake stimulation for 30 minutes daily over five days. Researchers will track changes in fatigue, brain ch…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

This study tests whether a specific exercise program called the GH Method can improve body composition, strength, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. About 25 veterans will do 90 exercise sessions over 18 months and comple…

This study tests whether an 8-week online Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in people with sarcoidosis. One group does MBSR with weekly sessions and daily journaling; the other joins a monthly virtual support group. Rese…

This study is testing whether squeezing a stress ball during chemotherapy can help reduce nausea, anxiety, and fatigue in people with stomach cancer. About 52 adults will take part. Researchers will measure their symptoms during treatment to see if this simple, drug-free tool mak…

This study tests whether walking exercise can reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who completed cancer treatment will walk either at a center or at home for 12 weeks. The goal is to see which approach works better for easing tiredness…

This study tests whether aerobic exercise or cognitive behavioral therapy can reduce fatigue in people with myasthenia gravis (MG). About 60 adults with stable MG will be randomly assigned to one of three groups: exercise, therapy, or usual care. The goal is to see if these appro…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study interviews 80 cancer survivors and their doctors to understand how they describe cancer-related fatigue. The goal is to create a visual aid (like a Venn diagram) that helps patients and providers communicate more effectively about this common symptom. The study does no…

This study follows 100 adults with Sjögren's disease for 3 months to understand what causes their fatigue. Researchers will use questionnaires and pain tests to track fatigue, mood, sleep, and activity levels. The goal is to find factors that predict or explain fatigue, which cou…

This study tests different ways to deliver exercise programs remotely to 257 adults with physical disabilities that limit mobility. Participants get access to recorded workout videos and weekly wellness articles, and some also receive health coaching or live training sessions. Th…

This study aims to understand how the brain decides how much effort to put into tasks, both mental and physical. Researchers will measure how fatigue and rewards change our perception of effort. 185 healthy adults aged 18-35 will complete tasks and undergo brain scans to map the …