EOSINOPHILIC ESOPHAGITIS

This study tests whether Zemaira, a drug that blocks certain enzymes, can help adults with eosinophilic esophagitis (EoE), a condition where immune cells build up in the esophagus and cause trouble swallowing. Fifteen participants will receive Zemaira infusions weekly for 4 weeks…

This study tests whether a daily pill called vonoprazan can reduce inflammation and improve swallowing in adults with eosinophilic esophagitis (EoE), a chronic allergic condition that damages the esophagus. About 80 participants will receive either vonoprazan or a placebo for 12 …

This study tests a new drug, EP-104GI, for adults with eosinophilic esophagitis, a condition that makes swallowing painful and difficult. About 160 participants will receive either the drug or a placebo during an endoscopy. The goal is to see if the drug is safe and reduces infla…

This study tests if taking a 2 mg budesonide tablet once a day works as well as taking 1 mg twice a day for adults with eosinophilic esophagitis, a condition where white blood cells damage the esophagus. About 308 adults with active disease will receive one of the two dosing sche…

This study is testing a new FDA-approved device that measures electrical signals in the throat to help doctors diagnose GERD and eosinophilic esophagitis more accurately. About 50 adults with chronic reflux or swallowing problems will use the device during an upper endoscopy. The…

This study checks if a simple, low-cost string test can diagnose eosinophilic esophagitis (EoE), a condition that causes trouble swallowing. Currently, diagnosis requires a camera tube down the throat (endoscopy). The string test involves swallowing a capsule with a string that c…

This study looks at whether children with eosinophilic esophagitis (a condition causing throat inflammation) can safely eat heated forms of egg or milk without symptoms returning. About 36 kids who are currently avoiding these foods will try gradually more heated versions. The go…

This study is testing whether simple, noninvasive tests—like urine, blood, and saliva samples—can accurately measure disease activity in children with eosinophilic esophagitis, a chronic allergic condition that inflames the esophagus. Currently, monitoring requires repeated endos…

This study aims to learn more about what causes food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will follow up to 1,800 people (ages 2-99) and their relatives for up to 12 years, collecting blood, skin, and genetic samples. The goal is …

This study is a registry that will collect medical information from up to 10,000 people with esophageal problems like GERD, achalasia, and other swallowing disorders. Researchers will gather data from standard tests to better understand these conditions. The goal is to improve di…

This small pilot study is looking at whether treating inflammation in the esophagus with proton pump inhibitors (PPIs) can improve how well the esophagus stretches and moves. Ten people with eosinophilic esophagitis (EoE) will have their esophagus flexibility measured before and …

This study follows 150 adults with eosinophilic esophagitis (EoE) who are starting dupilumab as part of their normal medical care in Germany. Researchers will collect information on patients' medical history, symptoms, quality of life, and any side effects over two years. The goa…

This study looks at a newly described condition called FIRE (Food Induced Immediate Response of the Esophagus) in children aged 6 to 17 who already have eosinophilic esophagitis. Researchers want to find out how common FIRE is and what symptoms it causes, like chest pain or choki…

This study is for children and adults with eosinophilic disorders affecting the esophagus, stomach, intestines, or colon. Researchers want to see if simple questionnaires can replace or improve the use of tissue samples from endoscopy to track disease activity. The goal is to fin…

This study tests a decision-support tool for adults with eosinophilic esophagitis (EoE). Researchers want to see if the tool helps patients learn about treatment options and feel more ready to choose a therapy. About 40 people from the University of Michigan will take part. The g…

This study creates a registry of up to 500 people with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect medical information, symptom reports, and tissue samples during routine care to learn…