END STAGE KIDNEY DISEASE

This phase 3 trial tested a sirolimus-coated collagen implant placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula mature faster and stay usable for dialysis. 136 people with kidney failure on hemodialysis took part. The implant is a on…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft, which would requir…

This study tested a special collagen implant that slowly releases sirolimus around a new dialysis fistula (the blood vessel connection used for dialysis). The goal was to see if it helps the fistula mature and stay usable for dialysis. The trial involved 269 adults with advanced …

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). The goal was to see if PLS240 can safely lower parathyroid hormone levels compared to a placebo. Participant…

This study compared two types of home dialysis for people with end-stage kidney disease: nighttime automated dialysis (APD) and daytime manual dialysis (CAPD). 137 non-diabetic adults tried each method for 12 weeks. The goal was to see if nighttime dialysis was as good as daytime…

This early-stage study tested a single dose of the experimental drug MK-2060 in 14 people with stage 4 chronic kidney disease to check its safety and how the body processes it. The trial was originally planned to also test multiple doses and include people on dialysis, but those …

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested a decision-making tool for people waiting for a kidney transplant. 100 participants used an online education tool and discussed their options with a doctor. The goal was to see if the tool helps patients feel more prepared and confident when deciding whether to …

This study looked at whether a 12-week cycling program during hemodialysis can reduce heart muscle stress (called stunning) in adults with end-stage kidney disease. 111 participants either cycled or rested during their dialysis sessions. Researchers measured heart function with u…

This study looked at how the drug MK-5684 moves through the bodies of men with severe kidney failure or end-stage kidney disease compared to healthy men. Twenty-four men took a single dose, and researchers measured drug levels in their blood over time. The goal was to understand …