END-STAGE KIDNEY DISEASE

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This study looks at two common heart medications, metoprolol and carvedilol, in people on dialysis. The goal is to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 adults on hemodialysis will be randomly assigned to one of the two drugs …

This study looks at whether starting dialysis twice a week instead of the usual three times a week can reduce hospital stays and improve quality of life for older adults (60+) with kidney failure who still produce some urine. The researchers will follow 428 participants for up to…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking immunosuppressive drugs. Ten adults with a well-functioning, HLA-matched kidney transplant will receive a conditioning treatment followed by …

This study is testing a new dialysis machine called Moda-flx for people with end-stage kidney disease who are already on stable dialysis. The goal is to see if the machine is safe and works well both in a clinic and at home when used by trained patients or care partners. About 50…

This study tests whether a once-daily pill called empagliflozin (a diabetes drug) is safe and can help preserve the small amount of kidney function that some people on peritoneal dialysis still have. About 20 adults who produce at least 250 mL of urine per day will take the drug …

This study tests whether a personalized, gradual start to dialysis is safer and improves quality of life compared to the standard fixed schedule. It involves 350 adults with end-stage kidney disease who recently started dialysis. Researchers will track hospital visits, overall he…

This study compares two ways of monitoring symptoms in people receiving dialysis for kidney failure. About 2,400 adults at up to 36 U.S. clinics will either use a tablet-based system that tracks symptoms and alerts their care team, or receive usual care. The goal is to see if reg…

This study tests whether using social virtual reality (VR) during dialysis sessions can reduce loneliness and other symptoms in people with end-stage kidney disease. Sixty participants will use VR glasses for 30-45 minutes, three times a week, for four weeks. Researchers will com…

This study looks at how the drug eloralintide enters the bloodstream and leaves the body in people with severe kidney disease or kidney failure, compared to healthy volunteers. About 28 participants will receive a single shot under the skin. The study lasts about 14 weeks and doe…

This study compares three ways to check for fluid overload (too much fluid in the body) in people doing dialysis at home. Researchers will ask about symptoms, do a physical exam, and use a safe ultrasound of the lungs. The goal is to find which method works best to help prevent h…