END-STAGE KIDNEY DISEASE

This study tested a special collagen implant that slowly releases a drug called sirolimus. It was placed around the new blood vessel connection (fistula) during surgery in 136 people with kidney failure who were on dialysis. The goal was to see if the implant helps the fistula ma…

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). The goal was to see if PLS240 can safely lower parathyroid hormone levels compared to a placebo. Participant…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft. Participants recei…

This study tested a special collagen implant that slowly releases sirolimus around a new dialysis fistula (a surgically created blood vessel connection). The goal was to see if it helps the fistula become usable for dialysis sooner and stay working well. The trial involved 269 ad…

This study compared two types of home dialysis for people with end-stage kidney disease: nighttime automated dialysis (APD) and daytime manual dialysis (CAPD). 137 non-diabetic adults tried each method for 12 weeks. The goal was to see if nighttime dialysis was as good as daytime…

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This early-stage study tested a single injection of MK-2060 in 14 people with advanced chronic kidney disease to check for side effects and how the drug moves through the body. Only the first part was completed; the later parts were not started for reasons unrelated to safety. Th…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested a decision-making tool for people waiting for a kidney transplant. 100 participants used an online education tool and discussed their options with a doctor. The goal was to see if the tool helps patients feel more prepared and confident when deciding whether to …

This study looked at whether a 12-week cycling program during hemodialysis can reduce heart muscle stress (called stunning) in adults with end-stage kidney disease. 111 participants either cycled or rested during their dialysis sessions. Researchers measured heart function with u…

This study looked at how the drug MK-5684 moves through the bodies of men with severe kidney failure or end-stage kidney disease compared to healthy men. Twenty-four men took a single dose, and researchers measured drug levels in their blood over time. The goal was to understand …