END STAGE KIDNEY DISEASE

This study tests whether a daily 25 mg dose of empagliflozin (a diabetes drug) is safe and helps preserve remaining kidney function in 20 adults on peritoneal dialysis. Participants must still produce at least 250 mL of urine daily. The trial measures changes in kidney filtration…

This study tests whether the drug patiromer can safely allow people on chronic dialysis to relax their strict low-potassium diet. About 40 participants will receive either patiromer or a placebo daily. The goal is to see if patiromer keeps potassium levels stable while patients e…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive a conditioning treatm…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This study looks at two common heart medications, metoprolol and carvedilol, in people on dialysis. The goal is to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 adults on hemodialysis will be randomly assigned to one of the two drugs …

This study looks at whether starting dialysis twice a week instead of the usual three times a week can reduce hospital stays and improve quality of life for older adults (60+) with kidney failure who still produce some urine. The researchers will follow 428 participants for up to…

This study is testing a new dialysis machine called Moda-flx for people with end-stage kidney disease who are already on stable dialysis. The goal is to see if the machine is safe and works well both in a clinic and at home when used by trained patients or care partners. About 50…

This study tests whether a personalized, gradual start to dialysis is safer and improves quality of life compared to the standard fixed schedule. It involves 350 adults with end-stage kidney disease who recently started dialysis. Researchers will track hospital visits, overall he…

This study tests whether a digital symptom tracking system (SMaRRT-HD) helps dialysis patients feel better by alerting their care team to issues. About 2,400 adults on hemodialysis at up to 36 U.S. clinics will either use the system or receive usual care for 12 months. The goal i…

This study tests whether using social virtual reality (VR) during dialysis sessions can reduce loneliness and other symptoms in people with end-stage kidney disease. Sixty participants will use VR glasses for 30-45 minutes, three times a week, for four weeks. Researchers will com…

This study looks at how the drug eloralintide enters the bloodstream and leaves the body in people with severe kidney disease or kidney failure, compared to healthy volunteers. About 28 participants will receive a single shot under the skin. The study lasts about 14 weeks and doe…

This study compares three ways to check for fluid overload (too much fluid in the body) in people doing dialysis at home. Researchers will ask about symptoms, do a physical exam, and use a safe ultrasound of the lungs. The goal is to find which method works best to help prevent h…