DIFFERENTIATED THYROID CANCER

This study is testing whether a drug called larotrectinib can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has spread to the lungs and has a specific genetic change (NTRK fusion). Participants will take larotrectinib for six months, …

This large study aims to find out if a less extensive surgery (removing only half the thyroid) is just as good as removing the whole gland for patients with low-risk thyroid cancer. It will compare cancer recurrence rates, side effects like voice changes, and quality of life betw…

This study is for children and young adults with advanced thyroid cancer that has spread to the lungs. Researchers want to see if taking new 'targeted' drugs for about a month makes the cancer absorb radioactive iodine better. If it works, this could help doctors use a standard t…

This study is testing if a drug called selpercatinib can make a standard thyroid cancer treatment (radioactive iodine) work better for children and young adults. It focuses on patients aged 2-25 with a specific genetic change (RET fusion) in their cancer. The goal is to see if ta…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This study is testing a new type of PET/CT scan to see if it can find thyroid cancer tumors better than the current standard scan. It is for people who have had surgery and radioactive iodine treatment but still have signs of cancer in their blood. The goal is to improve detectio…

This study aims to find out if following a strict low-iodine diet for 7 days increases how much radioactive iodine the body absorbs. Researchers will measure this in 25 adults who have had surgery for thyroid cancer and are scheduled for radioactive iodine therapy. The goal is to…