CUTANEOUS MELANOMA

This study tested whether adding denosumab (a bone-strengthening drug) to standard immunotherapy (pembrolizumab or nivolumab) could help control advanced melanoma. 25 adults with stage III or IV melanoma that could not be removed by surgery took part. The goal was to see if denos…

This early-phase study tested a new treatment called TBio-4101 for people with advanced melanoma that had stopped responding to standard therapies. The treatment uses a patient's own immune cells (TILs) that are selected and grown in the lab, then given back after chemotherapy to…

This completed study involved 127 people with cutaneous melanoma. Researchers measured levels of the IL4I1 enzyme in blood and tumor tissue to see if it helps predict how fast the disease progresses and whether it plays a role in resistance to common treatments like immunotherapy…

This study tested a method to identify immune cells (T cells) that recognize unique mutations in tumors from breast cancer or melanoma patients. Researchers looked at lymph nodes invaded by cancer to see if they could find and measure these cells. The goal was to see if the metho…

This study looked at whether a special training program for primary care doctors could help them better find and treat early-stage melanoma, a serious skin cancer. Fifty-four doctors from two clinics took part. The goal was to see if the training improved their knowledge and skil…