Virus therapy shows promise for Tough-to-Treat melanoma
NCT ID NCT04577807
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 30 times
Summary
This study tested a new treatment called lerapolturev, a modified polio virus, alone or combined with an immunotherapy drug, in 27 adults with advanced melanoma that no longer responded to PD-1 inhibitors. The goal was to see if the virus could shrink tumors or improve survival. Participants received the treatment directly into tumors, and researchers monitored side effects and immune responses.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cancer Treatment Centers of America
Zion, Illinois, 60099, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Henry Ford Health System
Detroit, Michigan, 48208, United States
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HonorHealth Research Institute
Scottsdale, Arizona, 85258, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Orlando Health U7 Health Cancer Center
Orlando, Florida, 32806, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Texas Oncology -Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
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University of Pittsburgh Hillman Cancer Center
Pittsburgh, Pennsylvania, 15213, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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West Virginia University Medical Center
Morgantown, West Virginia, 26506, United States
Conditions
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