Cutaneous melanoma
Clinical trials for Cutaneous melanoma explained in plain language.
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New drug combo aims to shrink melanoma before surgery
Disease control Not yet recruitingThis study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink melanoma tumors in people with stage IIIB to IV melanoma. About 35 adults will receive the drugs, then have surgery to remove any remaining cancer. The main goal is to see…
Matched conditions: CUTANEOUS MELANOMA
Phase 2 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Can a DNA repair gene flaw make melanoma vulnerable to chemotherapy?
Disease control Not yet recruitingThis phase II trial tests whether the chemotherapy drug temozolomide can shrink tumors in people with advanced or metastatic melanoma that has a mutation in the BAP1 gene. BAP1 normally helps repair damaged DNA, and when it is faulty, cancer cells may become more sensitive to cer…
Matched conditions: CUTANEOUS MELANOMA
Phase 2 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Can a short Pre-Surgery immunotherapy course replace Long-Term adjuvant treatment for melanoma?
Disease control Not yet recruitingThis phase 2 trial is investigating whether giving immunotherapy before surgery for advanced melanoma (stage IIIB to IV M1a) can maintain survival while allowing patients to skip the usual adjuvant therapy after surgery. Participants are randomly assigned to receive either two in…
Matched conditions: CUTANEOUS MELANOMA
Phase 2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Triple drug attack on melanoma: new trial hopes to boost surgery success
Disease control Not yet recruitingThis phase 2 trial tests three immune-boosting drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery in 20 people with advanced but removable melanoma. The goal is to see if the combination is safe and can shrink tumors, potentially improving outcomes. Participants m…
Matched conditions: CUTANEOUS MELANOMA
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Magnetic tracer could replace radioactive dye in melanoma surgery
Diagnosis Not yet recruitingThis phase 3 trial tests whether a magnetic tracer (Magtrace) works as well as the standard radioactive dye plus blue dye for finding sentinel lymph nodes in people with melanoma. About 254 adults having surgery for melanoma will receive both tracers and be randomly assigned to h…
Matched conditions: CUTANEOUS MELANOMA
Phase 3 • Sponsor: Vastra Gotaland Region • Aim: Diagnosis
Last updated Sep 05, 2026 00:00 UTC
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Your gut bacteria may hold the key to whether immunotherapy works
Knowledge-focused Not yet recruitingResearchers are studying whether the mix of bacteria in a person's gut can predict how well they respond to immunotherapy drugs called immune checkpoint inhibitors. The trial enrolls about 360 adults with advanced non-small cell lung cancer, melanoma, endometrial cancer, or cervi…
Matched conditions: CUTANEOUS MELANOMA
Sponsor: European Institute of Oncology • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC
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Can a simple paper tool help melanoma patients make tough biopsy decisions?
Knowledge-focused Not yet recruitingThis study tests a paper-based decision aid designed to help people with intermediate-risk melanoma decide whether to have a sentinel lymph node biopsy. The tool provides clear information about the procedure, its risks and benefits, and helps patients think about their personal …
Matched conditions: CUTANEOUS MELANOMA
Sponsor: University of Virginia • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Could skipping a lymph node test be just as good for older melanoma patients?
Knowledge-focused Not yet recruitingThis study looks at whether older adults (75+) with early-stage melanoma can safely skip an extra lymph node biopsy after their main surgery. The goal is to see if the simpler surgery alone works just as well and improves overall well-being. About 428 participants will be followe…
Matched conditions: CUTANEOUS MELANOMA
Phase 3 • Sponsor: Eastern Cooperative Oncology Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC