CUTANEOUS MELANOMA

This study tests a new treatment called RP1, a virus that attacks cancer cells, combined with the immunotherapy drug nivolumab. It includes 340 adults with advanced solid tumors such as melanoma, non-small cell lung cancer, and certain skin cancers. The goal is to see if the comb…

This study tests whether giving the drug atezolizumab before surgery is safe for people with high-risk melanoma that hasn't spread. About 20 participants will receive two doses before their operation. The goal is to see if this approach can help control the disease and reduce the…

This Phase 2 trial tests a new drug called acasunlimab, given alone or with pembrolizumab, in adults with advanced melanoma that worsened after standard treatment. The goal is to see if the combination can shrink tumors or slow cancer growth. Participants receive active treatment…

This small pilot study looks at whether doing 20-30 minutes of moderate exercise right before immunotherapy can help the treatment work better for people with certain skin cancers (melanoma, squamous cell carcinoma, and Merkel cell carcinoma). The study includes 12 adults schedul…

This early-phase study tests a new drug called KFA115, alone or with pembrolizumab, in people with advanced cancers like lung, melanoma, and kidney cancer. The main goal is to find a safe dose and understand side effects. About 126 participants will take part to see if the treatm…

This early-phase study tested a personalized vaccine (NeoVax) made from a patient's own tumor mutations, combined with two immunotherapy drugs (nivolumab and ipilimumab), in 11 people with advanced melanoma that could not be removed by surgery. The main goal was to check safety a…

This study looks at whether giving the immunotherapy drug pembrolizumab for one year works just as well as the usual two-year course for people with advanced melanoma that has spread. The trial involves 29 adults in Brazil whose melanoma cannot be removed by surgery or cured. The…

This early-phase study tests whether 30 minutes of moderate exercise (like cycling or walking) right before each immunotherapy treatment can help the body fight skin cancers such as melanoma. The study involves 22 adults who are about to start standard immunotherapy. Researchers …

This early-stage study tests the safety of a new drug, PF-08046049/SGN-BB228, in people with advanced melanoma and other solid tumors that have spread or are hard to treat. The study involves 41 participants and will look at side effects and the right dose. It is not expected to …

This study collects fresh tumor samples from 416 adults with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) to develop and train a live tumor diagnostic platform. The goal is to see how accurately the platform can predict whether a pa…