CROHN DISEASE (CD)

This early-phase study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goals are to check safety and find the best dose, while also looking at how well it wo…

This study tests whether a probiotic called Clostridium butyricum, alone or with a sugar called trehalose, can help prevent scarring in the gut of people with Crohn's disease. About 40 adults with a scarring type of Crohn's will take one of these treatments or a placebo for two m…

This study tests whether mirikizumab can heal deep intestinal damage in people with Crohn's disease. About 110 adults with active symptoms and visible inflammation on MRI will receive the drug and be checked at 24 weeks. The goal is to see if the treatment reduces inflammation en…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). About 76 adults with IBD and moderate-to-severe anxiety will use either the VR therapy or a…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 adults with long-term fatigue will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a large…

This study tests a new imaging method to see if two IBD drugs (adalimumab and risankizumab) actually reach the inflamed gut tissue. 30 adults with ulcerative colitis or Crohn's disease will receive a tiny dose of fluorescent-labeled drug before a routine colonoscopy. The goal is …

This study will interview 15 adults with stricturing Crohn's disease to learn which symptoms matter most to them and how the condition affects daily life. The goal is to use patient experiences to create a better way for doctors to measure and track the disease. Participants will…

This study aims to learn how well people with Crohn's disease or ulcerative colitis follow a daily vitamin D supplement routine over 12 months. Researchers will also check if vitamin D improves quality of life and disease activity. About 150 adults will take 2,000 IU of vitamin D…

This study looks at how diet affects inflammation in people with Crohn's disease or ulcerative colitis. About 140 participants will either follow a Nordic test diet for six weeks or use a digital information tool. Researchers want to see if these approaches can lower inflammation…

This study looks at whether an MRI without a bowel-distending drink (like PEG or mannitol) can still accurately measure inflammation in the small bowel of people with Crohn's disease. Many patients find the drink hard to tolerate, causing vomiting or diarrhea. If skipping it work…

This study aims to see if data from smartwatches and smartphones can detect when inflammatory bowel disease (IBD) symptoms get worse. About 80 adults with Crohn's disease or ulcerative colitis will wear a smartwatch and use an app while shopping at Colruyt stores. Researchers wil…

This study is testing a way to predict who might develop Crohn's disease by looking at blood markers and lifestyle habits. It will follow 10,000 close relatives (parents, siblings, or children) of people with Crohn's, aged 16 to 35, for several years. Participants give blood and …

This study looks at intestine tissue removed during surgery from 60 adults with Crohn's disease. Researchers will use special MRI scans and lab tests on the tissue to better understand the difference between active inflammation and permanent scarring. The goal is to improve futur…