CROHN DISEASE (CD)

This study tests whether adding a special diet (the Crohn's Disease Exclusion Diet, or CDED) to standard infliximab therapy helps children with Crohn's disease achieve better control of their condition. About 140 children starting infliximab will be randomly assigned to receive e…

This study is following about 4,000 people who have received a fecal microbiota transplant (FMT) to see how well it works over time and if it's safe. FMT involves putting healthy donor stool into a patient's gut to restore good bacteria. The study looks at conditions like severe …

This study tests a new way to prevent Crohn's disease from returning after bowel surgery. Instead of waiting 6 months for a colonoscopy, doctors will check a stool marker (fecal calprotectin) at 3 months and adjust treatment early if needed. The goal is to reduce the number of pe…

This study looks at whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely take less of the drug ustekinumab without their disease coming back. About 115 participants will either stretch their injections from every 4 weeks to every 8 weeks,…

This study tests a new surgical approach for people with Crohn's disease affecting the last part of the small intestine. The surgery removes the diseased section and a portion of surrounding tissue, then reconnects the bowel using a special technique (Kono-S anastomosis). Researc…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF medication can improve symptom control in adults with active Crohn's disease or ulcerative colitis. About 80 participants will be split into two groups: one gets m…

This study tests whether adding a low dose of upadacitinib to standard TNF inhibitor therapy works better than increasing the TNF inhibitor dose alone for people with moderate-to-severe Crohn's disease who aren't getting enough benefit from their current treatment. About 312 adul…

This study tests whether switching to a drug called guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who did not get enough relief from ustekinumab. About 200 adults across Canada will take guselkumab for one year, and doctors will track their symptoms a…

This study tests whether infusions of donor stem cells can reduce Crohn's disease symptoms better than a placebo. 46 adults with Crohn's will receive either stem cells or a dummy infusion over 16 weeks, then be followed for a year. The main goal is to see if the treatment lowers …

This study is testing whether a smartphone app called SMART-IBD can help teenagers (ages 13-17) with inflammatory bowel disease (IBD) take their medications as prescribed and improve their self-management skills. The app includes daily symptom diaries, medication reminders, educa…

This study tests an experimental treatment called EXL01 to see if it can prevent Crohn's disease from returning after bowel surgery. About 80 adults who recently had surgery for Crohn's will take either EXL01 or a placebo daily for up to 24 weeks. Doctors will use a camera to che…

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) to eat fewer ultra-processed foods (like chips, soda, and fast food) can improve their health. About 120 participants will track their eating online and receive either a handout or a han…

This study tests whether a daily cranberry supplement can help restore healthy gut bacteria in adults with Crohn's disease. About 50 participants will take either the supplement or a placebo for 10 weeks. Researchers will track changes in gut bacteria, inflammation, and symptoms …

This study tests whether using a blood test that looks at epigenetic markers can help doctors choose the best biologic drug for people with active Crohn's disease. About 378 adults will be randomly assigned to either have their treatment chosen by this test or by the usual doctor…

This study compares using plain water versus the usual polyethylene glycol (PEG) solution as a bowel preparation for magnetic resonance enterography (MRE) in people with Crohn's disease. About 194 participants will be randomly assigned to drink either water or PEG before their sc…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or indeterminate colitis) in Germany over many years. Researchers will collect real-world information on disease activity, treatment effectiveness, …

This study looks at whether ultrasound can be used instead of CT scans to check for muscle loss (sarcopenia) in people with Crohn's disease or ulcerative colitis. Researchers will compare ultrasound measurements with CT scans in 100 adults. If ultrasound works well, it could offe…