COLORECTAL CANCER METASTATIC

This study tests a combination of three drugs (trifluridine/tipiracil, capecitabine, and bevacizumab) in people with metastatic colorectal cancer who have not had chemotherapy for their advanced disease and are not eligible for intensive treatment. The goal is to find a safe dose…

This study tests two drug combinations for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. In one group, patients who haven't had treatment before will get the drugs IBI351 and cetuximab plus chemotherapy. In another group, patients who…

This study is for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation and has stopped responding to standard treatments. Researchers are testing the safety and effectiveness of combining two drugs, AVUTOMETINIB and cetuximab. The goal …

This study looks at whether adding tocotrienol (a compound related to vitamin E) to standard chemotherapy and bevacizumab can help people with metastatic colorectal cancer. About 83 participants will receive either tocotrienol or a placebo for up to six months. The main goal is t…

This study tests whether adding a targeted chemotherapy directly into the liver (via tiny beads) to standard全身化疗 can better shrink tumors in people with colorectal cancer that has spread only to the liver and has a poor outlook. About 48 adults will be randomly assigned to receiv…

This early-stage trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in 120 adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goal is to find safe doses and check for side effects, while also measur…

This study aimed to see if adding a new drug (LY3200882) to a standard chemotherapy (capecitabine) could help people with advanced colorectal cancer that no longer responded to treatment. It was designed for patients whose tumors had a specific genetic signature. However, the stu…

This study compares two treatments for colorectal cancer that has spread to the liver: surgical removal of the tumors versus a less invasive needle ablation technique that uses heat or cold to destroy them. About 230 patients will be randomly assigned to one of the two treatments…

This study looks at how small changes in CT scan settings affect the way tumors are measured in people with colorectal cancer that has spread to the liver. About 169 participants will get an extra CT scan to see if the measurements stay reliable even when scan details vary. The g…

This study looks at whether a simple blood test can find signs of cancer coming back after surgery for colorectal or appendix cancer that has spread to the belly lining. About 55 people who are having surgery plus heated chemotherapy will give blood samples before and after the p…