COLORECTAL ADENOCARCINOMA

This study tests whether a new drug called AK112, combined with chemotherapy, works better than the standard treatment (bevacizumab plus chemotherapy) for people with metastatic colorectal cancer that has spread. About 560 adults aged 18 to 75 who have not had prior treatment for…

This early-phase study tests a new drug, CLSP-1025, designed to direct immune cells to attack tumors that have a specific p53 R175H mutation. The trial enrolls adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have worsened after standard treatments.…

This early-phase study tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is a lab-made antibody designed to target and kill cancer cells. The main goals are to check safety and see if tumors shrink. Abo…

This study tests a new combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with HER-2 positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see how many patients' tumors shrink or …

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This early-stage study tests a new drug that delivers radiation directly to cancer cells. It is for people with advanced solid tumors like bladder, breast, lung, or cervical cancer that have not responded to prior treatments. The main goals are to find the safest dose and see if …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests a new microwave-based device, called MiWEndo, during colonoscopy in 50 patients who already have a polyp in their rectum. The goal is to see if the device can find more polyps safely without changing the usual procedure. The device has been tested in earlier lab …

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will test blood samples from 400 participants, incl…

This study is testing a new blood test that measures a protein called MMP14 to see if it can better detect colorectal cancer or precancerous growths. Researchers will enroll 650 adults aged 50-74 who already need a colonoscopy after a positive stool test. The goal is to find the …

This early-phase trial is testing whether fluoxetine (Prozac), a common antidepressant, can alter the immune cells inside colorectal tumors. About 10 adults with untreated colorectal cancer will take fluoxetine before their scheduled surgery. Researchers will compare tumor sample…

This study is testing whether a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer is likely to return. Researchers will collect blood samples from 1,000 people with colorectal cancer who have completed or ar…

This study is testing whether a new lab test can quickly identify which chemotherapy drugs work best for each person with advanced appendix or colorectal cancer that has spread to the abdomen. About 20 participants will have a small sample of their tumor tested, and the results w…

This study looks at whether a simple blood test after surgery for colorectal cancer can better predict if the cancer will come back. About 1,600 patients will give blood samples to check for leftover tumor DNA. If successful, this test could help doctors decide who really needs c…