Chronic apical periodontitis

This trial tests whether taking probiotics by mouth, along with standard root canal medications, can reduce pain and improve healing in people with chronic tooth infections. Participants will receive either a probiotic capsule or a placebo for 21 days, combined with one of three …

This study tested whether a single dental visit for regenerative root canal treatment works as well as the usual two-visit approach for mature teeth with chronic infection. Thirty-two adults received either a one-session or two-session procedure, and researchers tracked pain duri…

This study tested three different medications placed inside the tooth root after cleaning to see which one works best for reducing pain, fighting bacteria, and helping bone heal. 45 adults with a single infected tooth took part. The medications compared were N-acetylcysteine, cal…

This study tested three ways to clean infected root canals in 97 people with large tooth infections. The methods were manual movement, ultrasonic vibration, and laser activation. Researchers measured how much the infection shrank over one year using 3D scans. The goal was to find…

Researchers are testing whether a topical melatonin gel helps dental implants stay stable when placed immediately into tooth sockets that had chronic infection. Sixty adults with non-restorable teeth and long-standing apical lesions will receive either standard implant placement …

This study tested a more precise dental surgery for people with persistent root infections after standard treatment. Using a 3D-printed guide, surgeons aimed to remove infected tissue more accurately, reduce surgery time, and improve quality of life. The trial involved 70 adults …

This trial tests whether a nano-sized form of calcium hydroxide, placed inside the tooth after cleaning, reduces pain following root canal treatment compared to the conventional version. Adults aged 18 to 65 with a dead nerve in a single-rooted tooth and an infection at the tip o…

This trial tests whether placing a nano-form of the painkiller ketorolac inside the root canal can reduce pain after root canal treatment. Adults aged 18–50 with an infected tooth nerve will receive either nano-ketorolac, regular ketorolac, or a placebo gel during the procedure. …

This study tests whether a simple technique called apical patency—passing a tiny file slightly beyond the root tip during root canal treatment—can reduce pain afterward. Adults with an infected front tooth will be randomly assigned to receive treatment with or without this extra …

This study looked at three different root canal sealers to see if any caused less pain or helped teeth heal faster. Seventy-two adults with infected single-rooted teeth received standard root canal treatment with one of the sealers. Pain was checked right after, at 24 hours, and …

This study looked at 120 adults needing a root canal to see if one sealer (AH Plus or WellRootST) causes less pain afterward. Pain was checked before treatment and at several points up to one month later. The goal is to help dentists choose the better option for patient comfort.

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PR…

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and …

This study looked at whether using a special laser (Nd:YAG) during root canal treatment could help reduce inflammation and oxidative stress in infected teeth. Researchers measured certain markers in fluid samples from 58 patients. The results showed that the laser did not provide…