CENTRAL NERVOUS SYSTEM TUMOR

This early-stage study is testing a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose and check for side effects. The study is…

This study tests an experimental drug called ONC206 in children and young adults with a type of brain tumor called diffuse midline glioma (DMG) or other recurring brain cancers. The drug works by causing stress in cancer cells, making them die without harming healthy cells. The g…

This study tests whether a machine learning tool can accurately predict which patients are at high risk for surgical site infection after brain or spinal tumor surgery. About 500 adults scheduled for tumor removal will have their infection risk calculated within 72 hours after su…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This program gives children and young adults with central nervous system or head and neck tumors access to a special PET scan that uses a tracer called methionine. The scan helps doctors see the tumor more clearly and make better treatment decisions. Anyone under care at St. Jude…

This study collects leftover tumor tissue from surgery or autopsy in people with central nervous system (CNS) tumors. Researchers will use the tissue to create lab models and test how different drugs work. The goal is to learn more about these tumors and find better treatment opt…

This study looks at 50 twins where only one has a childhood brain tumor. Researchers will compare DNA from blood and saliva samples to find small genetic differences that might explain why one twin got sick. The goal is to better understand what causes these cancers, not to test …

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…