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Gut bacteria linked to cancer survivor symptoms?

NCT ID NCT07450872

Knowledge-focused Sponsor: The Children's Hospital of Zhejiang University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 600 childhood cancer survivors aged 8-18 to understand why symptoms like fatigue, pain, and depression often occur together. Researchers will use questionnaires and stool samples to see if gut bacteria and their byproducts play a role. The goal is to find better ways to manage these symptoms and improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to manage symptoms like fatigue and pain in childhood cancer survivors, improving their quality of life.
What could go wrong
This is an observational study, so it won't test a treatment. The findings may not lead to direct changes in care, and results might not apply to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will recruit childhood cancer survivors (CCS) aged 8-18 years and their primary caregivers. Eligible CCS have a clinically confirmed diagnosis of cancer (including leukemia, lymphoma, central nervous system tumors, and other common solid tumors) and are in the rehabilitation/maintenance phase or have completed treatment ≥6 months prior to enrollment. Participants must have no cognitive impairment and be able to understand, communicate, and complete assessments. Primary caregivers aged ≥20 years who provide daily care for eligible CCS will also be included. All participants will provide informed consent/assent. This cohort captures diverse cancer types and survivorship stages to examine symptom clusters, their longitudinal trajectories, and related psychosocial and biological factors, including gut microbiota and metabolites.

Ages

8 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Children: * Aged 8-18 years; * Clinically and pathologically confirmed diagnosis of cancer (including leukemia, lymphoma, central nervous system tumors, or other common solid tumors); * Currently in the rehabilitation/maintenance phase or completed treatment ≥6 months prior to enrollment; * No cognitive impairment; able to understand, communicate, and complete questionnaires independently; * Written informed consent/assent obtained from participants and their legal guardians. Exclusion Criteria for Children: * Presence of severe treatment-related sequelae (e.g., significant organ dysfunction or neurological impairment) that may interfere with symptom assessment; * Poor compliance or inability to independently complete interviews/questionnaires; * Concurrent participation in other interventional clinical trials that may influence study outcomes; * Planned major surgery or initiation of new chemotherapy/radiotherapy during the study period. Inclusion Criteria for Caregivers: * Primary caregiver of an eligible CCS participant; * Aged ≥20 years; * Able to understand study content and complete questionnaires, with adequate literacy and communication ability; * Written informed consent provided prior to participation. Exclusion Criteria for Caregivers: * Experience of major adverse life events within the past 6 months (e.g., bereavement, divorce) that may affect psychological assessment * Presence of severe cognitive impairment; * Presence of severe aphasia, psychiatric disorders, or other conditions preventing independent completion of assessments.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia cancer central nervous system cancer central nervous system neoplasm glioma leukemia lymphoma neoplasm syndromic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer GLIOMA Leukemia (both all and AML)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Children's Hospital Zhejiang University School of Medicine

    RECRUITING

    Hangzhou, Zhejiang, 310057, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.