AORTIC DISSECTION

This study tests whether the anti-inflammatory painkiller ketorolac can improve outcomes for 360 people undergoing emergency surgery for a severe tear in the main artery from the heart (Stanford Type A aortic dissection). Participants receive either ketorolac or a placebo before …

This early study tests a new implant made of shape memory polymer to block blood flow in the false lumen of an aortic dissection. The goal is to prevent the aorta from growing and reduce complications. About 30 adults with type A or B aortic dissection who need false lumen treatm…

This study tests whether adding a special stent during emergency surgery for a torn aorta (the body's largest artery) can prevent future complications. About 72 adults with a specific type of aortic tear will be randomly assigned to get standard surgery or standard surgery plus t…

This study is testing a device called a valved graft for people who need surgery to replace a heart valve or repair the main artery (aorta). About 260 participants will receive the device and be followed to see how well it works and if it is safe. The main goals are to measure su…

This study tests whether doctor-modified grafts can safely repair complex aortic aneurysms in patients who are too high-risk for standard surgery. About 220 participants with abdominal or thoracoabdominal aneurysms or aortic dissections will receive the custom graft. The goal is …

This study is testing a new device called the NEXUS Aortic Arch Stent Graft System to treat serious conditions in the main artery near the heart, such as aneurysms, dissections, and ulcers. About 110 adults will receive the stent graft through a minimally invasive procedure. The …

This study tests a new device called the GORE Ascending Stent Graft to treat a life-threatening tear in the main artery from the heart (type A aortic dissection). The device is placed inside the artery through a small incision, avoiding major open-heart surgery. The trial will en…

This study is testing a new surgical approach called B-SAFER for people with aortic aneurysms, dissections, or congenital aortic problems. The procedure uses a branched stent to repair the aorta in a single operation. The goal is to see if it is safe and effective, with a focus o…

This study is testing three custom-designed stents to treat complex aneurysms in the main artery (aorta) that standard devices cannot fix. The goal is to see if these less-invasive stents can lower the risk of death, lung problems, and hospital stay compared to open surgery. Abou…

This study is creating a large collection of blood, tissue, and health information from 15,000 people, including those with heart conditions like aortic aneurysm and heart failure, as well as healthy volunteers. The goal is to provide researchers with a valuable resource to bette…

This study is collecting health information from 5,000 people who have a genetic risk for heritable thoracic aortic disease (H-TAD), a condition that can cause dangerous bulges or tears in the aorta. Researchers want to learn how different gene changes affect the disease and what…

This study aims to create a checklist of signs and symptoms that can reliably tell doctors when a CT scan is not needed after a blunt injury (like a car crash). By studying 12,000 emergency room patients, researchers hope to reduce unnecessary scans, which expose people to radiat…

This study compares two surgical techniques for repairing a torn aorta (aortic dissection) in 50 adults. Participants are randomly assigned to one surgery or the other. Researchers track who survives and who needs additional procedures over 3 years. The goal is to determine which…