ALS

This early-stage study tests whether siplizumab is safe for people recently diagnosed with ALS (Lou Gehrig's disease). About 48 adults will receive the drug and be monitored for 52 weeks. The goal is to check for side effects and see how the drug behaves in the body, not yet to p…

This early study tests a device implanted in a blood vessel in the brain that lets people with ALS control computers or devices just by thinking. The goal is to help with daily tasks and improve quality of life. Ten adults with ALS who have weakness in both arms will be enrolled …

This early-stage study tests a new medicine called AMX0114 in 48 adults with ALS. The main goal is to see if the drug is safe and tolerable. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves through the bo…

This study tests a brain-computer interface (BCI) implant for people with ALS or motor neuron disease who have weakness in both arms. The device aims to let them control computers or other devices just by thinking. The main goal is to check safety, such as serious side effects, o…

This program offers the drug ibudilast to people with ALS who cannot join other clinical trials. The goal is to see if ibudilast can slow down the disease. Participants must meet specific criteria, such as being over 18 and having a confirmed ALS diagnosis. The program aims to pr…

This study tests a brain-computer interface (iBCI) that reads movement-related brain signals to let people with severe paralysis (from ALS, spinal cord injury, or brainstem stroke) control a tablet computer just by thinking. The goal is to restore fast, natural communication usin…

This study looks at whether people with ALS who have trouble breathing can start using a noninvasive ventilator (a mask that helps them breathe) at home instead of in the hospital. Researchers will track how many hours patients use the machine each day, whether they stick with it…

This study tests whether combining two types of breathing exercises can help people with ALS cough stronger and breathe easier. About 34 participants will practice lung volume recruitment and expiratory muscle strength training. The goal is to improve lung function, reduce shortn…

This early-stage study tests whether a special helmet using sound waves can safely open a small part of the brain's protective barrier in people with ALS. This allows a powerful anti-inflammatory medicine (IVIg) to reach the motor cortex, the brain area controlling movement. The …

This study uses special PET scans to measure inflammation in the brains of people with diseases like Alzheimer's, Parkinson's, and ALS, compared to healthy volunteers. Researchers want to see if certain proteins called COX-1 and COX-2 are higher in diseased brains. About 184 adul…

This study enrolls family members of people with inherited ALS who do not yet have symptoms. Researchers provide genetic counseling and testing, then follow participants yearly to track when and how early signs of the disease appear. The goal is to gather information that could l…

This study is looking for better ways to measure how ALS progresses over time. Researchers will use MRI scans of the brain and spine, along with blood tests, to track changes in 90 people with ALS and healthy volunteers over one year. The goal is to find reliable markers that can…

This study is building a large database of health information from people with ALS and other motor neuron diseases. Researchers will collect details like symptoms, test results, and survival data during regular clinic visits. The goal is to help scientists better understand how t…

This study explores whether high-density brain surface recordings can decode imagined Mandarin Chinese speech, including tones, without any actual speaking. About 50 adults with brain conditions like epilepsy or tumors, plus 10 with severe speech loss from stroke or ALS, will hav…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode intended movements or speech, aiming to restore communica…