ALS
Clinical trials for ALS explained in plain language.
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New ALS drug trial aims to slow disease and improve survival
Disease control Not yet recruitingThis study tests a new drug called PLL001 in 153 adults with ALS (Lou Gehrig's disease). The goal is to see if it is safe and can slow the disease, improve daily function, and extend survival. Participants will receive daily injections of PLL001 or a placebo for up to 48 weeks, w…
Matched conditions: ALS
Phase: PHASE1, PHASE2 • Sponsor: PLL TX AUSTRALIA PTY LTD • Aim: Disease control
Last updated May 26, 2026 02:55 UTC
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New pill aims to slow ALS progression in early trial
Disease control Not yet recruitingThis early-stage trial tests an oral drug called Kamlanoflast in 40 people with ALS. The goal is to see if it is safe, tolerable, and can reduce inflammation or slow functional decline over 24 weeks. Participants must be 18-75 years old, diagnosed with ALS within the last 3 years…
Matched conditions: ALS
Phase: PHASE1, PHASE2 • Sponsor: Inflammasome Therapeutics • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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Smartphone app could spot early signs of speech decline in ALS
Knowledge-focused Not yet recruitingThis study will test if a smartphone app can reliably measure speech and breathing changes in Spanish-speaking people with ALS. Researchers will compare 35 ALS patients to healthy volunteers over time. The goal is to develop digital biomarkers that help track disease progression …
Matched conditions: ALS
Sponsor: Nova Southeastern University • Aim: Knowledge-focused
Last updated May 26, 2026 02:57 UTC
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New screening study aims to Fast-Track ALS patients to targeted trials
Knowledge-focused Not yet recruitingThis observational study screens 500 people with early-stage ALS (within 24 months of weakness onset) to see if they are eligible for specific early-phase ALS trials. Participants undergo clinical tests, lab work, and biomarker analysis. The study also builds a bank of blood samp…
Matched conditions: ALS
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 02:54 UTC
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New PET tracer could reveal hidden brain inflammation in ALS
Knowledge-focused Not yet recruitingThis early-phase study tests a new radioactive tracer called [11C]CPPC for PET scans in 20 people with ALS and healthy volunteers. The goal is to see if the tracer can safely detect brain inflammation linked to ALS and track changes over time. This research aims to improve unders…
Matched conditions: ALS
Phase: PHASE1, PHASE2 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated May 12, 2026 13:42 UTC