Urinary tract infection

This study tests a new vaccine designed to prevent urinary tract infections (UTIs) caused by E. coli bacteria. Researchers will check safety and immune response in 448 adults aged 18-64, and then see if it works in women of the same age. Participants receive either the vaccine or…

This study tests a new treatment called LBP-EC01, which uses specially designed viruses (bacteriophages) to attack drug-resistant E. coli bacteria that cause urinary tract infections (UTIs). About 318 adults with a history of UTIs and a current infection will receive either LBP-E…

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This study looks at two ways to manage recurrent urinary tract infections (UTIs) in women. One group takes a daily antibiotic called nitrofurantoin. The other group has a minor procedure to burn away tiny spots in the bladder (electrofulguration) and also takes the daily antibiot…

This study tests whether using an antibiotic (gentamicin) in the irrigation fluid and a special suction tube during kidney stone surgery can lower the chance of fever, inflammation, or sepsis afterward. About 180 adults having this surgery will be randomly assigned to receive one…

This study tests whether a bladder wash with a low-dose antiseptic (chlorhexidine) during routine catheter changes can reduce urinary tract infections and unplanned healthcare visits. Seventy adults with a long-term suprapubic catheter and a history of UTIs will receive the wash …

This study tests whether a simple technique called double voiding—urinating twice in one bathroom visit—can reduce urinary tract infections (UTIs) in kidney transplant recipients. UTIs are common after transplant and can lead to serious complications. The trial will compare doubl…

This study tests whether taking a short course of antibiotics (ciprofloxacin) after Botox injections into the bladder can reduce the chance of urinary tract infections. About 160 adults with neurogenic overactive bladder (due to conditions like multiple sclerosis or spinal cord i…

This study tests whether adding hydrogen peroxide fogging or ultraviolet light to regular cleaning can reduce infections in intensive care units. Over 5,000 adult patients in 12 Brazilian ICUs will take part. Each ICU will try all three methods (standard cleaning, cleaning plus h…

This study provides a fecal transplant product made from healthy donor stool to treat people with recurrent Clostridium difficile infection or multidrug-resistant urinary tract infections. The product is delivered by courier or FedEx after a contract is signed. The goal is to res…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This 6-month study tests whether a daily D-Mannose drink mix (FLUSH) can help women with a history of recurrent UTIs have fewer infections and better urinary health. About 210 adult women will be randomly assigned to one of three groups. Researchers will track how long it takes f…

This early-stage study tests whether a harmless bacterium called Lactobacillus crispatus, when placed directly into the bladder, is safe and can help prevent urinary tract infections (UTIs) in adults with spinal cord injury who use a catheter. Forty participants will receive two …

This study tests if rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after bladder cancer surgery can prevent urinary tract infections. About 23 adults having bladder removal and reconstruction will participate. The main goal is to see if urine is…

This study tests whether pivmecillinam pills work as well as standard antibiotics for treating febrile urinary tract infections (kidney infections) in adults. Participants who have already improved after 2-4 days of IV antibiotics will take pivmecillinam or continue standard care…

This early-phase trial tests the safety and tolerability of a new antibiotic called JKN2501 in 66 healthy adults in China. Participants receive either the drug or a placebo by IV infusion, and researchers monitor for side effects and how the drug moves through the body. The goal …

This study compares two ways to prevent repeat urinary tract infections (UTIs) in women after menopause. One group takes a nightly antibiotic pill for 6 months, while the other uses a vaginal tablet containing a probiotic (Lactobacillus) and a tiny amount of estrogen. The goal is…

This study tests whether taking the antibiotic ciprofloxacin for three days after bladder Botox injections reduces the risk of urinary tract infections in women with overactive bladder. About 202 women will be randomly assigned to receive either the antibiotic or a placebo pill. …

This study compares a new DNA-based test (PCR) to the standard urine culture for diagnosing urinary tract infections (UTIs) in adults. About 136 people with UTI symptoms will be randomly assigned to one of the two tests. Researchers will track how quickly treatment starts, how sy…

This study tests whether next-generation sequencing (NGS), a DNA-based method, can detect bacteria in urine when standard lab cultures show very low or no growth. About 100 women with UTI symptoms but inconclusive standard tests will provide urine samples for NGS analysis. The go…

This study looks at whether giving women a single dose of antibiotics right before a clinic-based urethral bulking procedure (for stress incontinence) can lower their chance of getting a urinary tract infection afterward. About 150 women will be split into two groups: one gets th…

This trial tests whether methenamine hippurate, a non-antibiotic antiseptic, can prevent urinary tract infections (UTIs) as effectively as standard antibiotics in women receiving BOTOX-A injections for overactive bladder. Participants will be randomly assigned to take either meth…

This pilot study tests whether applying a steroid cream to the foreskin for four weeks can prevent recurrent urinary tract infections (UTIs) in uncircumcised male infants under 6 months who have had their first fever-related UTI. Forty infants will receive either the steroid crea…

This study tests whether rinsing the bladder with Irrisept (a chlorhexidine solution) before removing a urinary catheter can prevent infections better than rinsing with salt water. Researchers will compare infection rates and antibiotic use in 300 adults. The goal is to find a no…

This study tests a vaginal gel called Multi-Gyn UT Protect to see if it can prevent repeated urinary tract infections (UTIs) in women. Fifty adult women who have had multiple UTIs in the past year but no current infection will apply the gel twice a week for four months. Researche…

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to se…

This phase 3 trial tests whether the drug U101 (pentosan polysulfate sodium) can prevent recurrent urinary tract infections (UTIs) in women aged 20 to 75. About 348 women with a history of frequent UTIs will take either U101 or a placebo daily for 24 weeks. Researchers will track…

This study tests whether washing the bladder with a harmless strain of E. coli can prevent recurrent urinary tract infections (UTIs) in people who have failed other treatments. Researchers will compare the harmless bacteria wash to a saltwater wash in 80 participants, tracking ho…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study looks at whether placing a small tube (stent) in the urinary tract after bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancers will be randomly assigned to get a stent or not. The main goal is to see if avoiding stents lowers the risk…

This study tests whether a short animated video and flyer, available in English and Spanish, can help patients collect cleaner urine samples. Contaminated samples often lead to wrong diagnoses and unnecessary antibiotics, which fuels antibiotic resistance. About 252 adults in pri…

This study looks at whether taking antibiotics before a procedure to treat stress urinary incontinence (leaking urine with cough or sneeze) can lower the chance of getting a urinary tract infection (UTI) afterward. About 138 women will receive either antibiotics or a placebo befo…

Complicated urinary tract infections are hard to treat and often return, and doctors need better data on what drives treatment failure. This observational study follows thousands of patients with confirmed complicated UTIs across multiple sites, collecting information on their sy…

This study looks at how doctors can improve antibiotic prescriptions for urinary tract infections (UTIs) after patients leave the emergency department. Researchers will check if adjusting antibiotics based on lab test results reduces the use of strong drugs like fluoroquinolones.…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study collects urine samples from adults who use intermittent catheters, both during urinary tract infections (UTIs) and during symptom-free periods. The goal is to explore basic urine characteristics, like bacterial counts, to better understand UTIs in this group. No treatm…

This study looks at how hyperbaric oxygen therapy (HBOT) affects symptoms and urine markers in people with chronic radiation cystitis, a bladder condition caused by past radiation treatment. Researchers will collect urine, blood, and tissue samples from 100 participants before, d…

This study tests a prediction model to help doctors decide if antibiotics are really needed for urinary tract infections (UTIs) in the emergency room. About 47 women with UTIs will be enrolled. The goal is to reduce unnecessary antibiotic use and fight antibiotic resistance.

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…