Tibia fracture

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take par…

This study tests whether personalized weight-bearing instructions using smart crutch tips can help heal tibia fractures faster. Thirty adults who had surgery for a broken shinbone will use sensor-equipped crutch tips that give real-time feedback on how much weight they put on the…

Researchers are collecting data on ViviGen, a donated cellular bone matrix used as a graft during orthopaedic surgery. The study follows patients with acute fractures, delayed healing, non-union fractures, or spinal fusion to see how often they need a second operation within a ye…

This Phase 3 trial tests whether antibiotic cement beads or negative pressure wound therapy (a wound vac) works better for severe open tibia fractures. 312 adults with these injuries will be randomly assigned to one of the two treatments. Researchers will compare death, amputatio…

This trial compares two surgical techniques for fixing a specific type of shinbone fracture in adolescents aged 10 to 16. Half the participants will receive elastic nails with small wires, and the other half will get a metal plate and screws. The study tracks how quickly the bone…

This study compares two surgical methods for treating severe tibial plateau fractures (Schatzker types V and VI) — a locking plate versus a hybrid Ilizarov external fixator. Adults aged 25 to 50 with such fractures will be randomly assigned to one of the two procedures. The main …

This trial compares two surgical techniques for repairing a broken shin bone (tibial shaft fracture) using a metal rod inside the bone. The two approaches—medial parapatellar and transpatellar—differ in how the surgeon reaches the bone. About 56 adults with acute tibial fractures…

This trial compares robot-assisted surgery to traditional methods for fixing a specific type of broken ankle (distal tibial fracture). The robot uses artificial intelligence to plan and perform the bone realignment, aiming for more accurate placement and less radiation exposure. …

This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The c…

This study compares a standard metal rod (nail) used to fix shinbone fractures with a new 'micromotion' nail that allows a tiny amount of movement at the break. Researchers want to see if the new nail helps bones heal faster and with fewer problems. About 100 adults with stable s…

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This study tests whether injecting N-acetylcysteine (NAC), an antioxidant, into the ankle right after a severe pilon fracture can keep cartilage cells alive and reduce the chance of developing post-traumatic arthritis. Thirty adults with closed high-energy pilon fractures will re…

This study tests whether special crutch tips with sensors can help heal a specific type of shinbone fracture. Thirty people who had surgery for a broken tibia will use the smart crutches for up to 24 weeks. The crutches give real-time feedback to guide how much weight to put on t…

This study tests whether special crutch tips that measure how much weight you put on your leg can help a broken shinbone heal better. Thirty people who had surgery for a tibial fracture will use the smart tips for up to 24 weeks, following a personalized walking plan based on CT …

This study is testing special screws that dissolve over time, used in foot and ankle surgeries for fractures, realignments, or joint fusions. The screws are meant to hold bones together while they heal, then safely absorb into the body. Researchers will follow 125 adults for 4 ye…

This study is testing a special 3D-printed cage called the TRUMATCH Graft Cage to help repair large bone defects in the arm or leg. Five adults with hard-to-heal breaks will receive the cage during surgery. Researchers will track healing, complications, and recovery time over thr…

This study compares two types of surgery for unstable ankle fractures in frail adults aged 60 and older. One group gets ankle fusion (joining the bones together), and the other gets open reduction and internal fixation (using plates and screws to hold the bones in place). A secon…

This study tests a new type of metal nail coated with a noble metal alloy to fix broken shin bones (tibia fractures). The goal is to see if it reduces the chance of infection compared to standard uncoated nails. About 500 adults with high-risk fractures will be followed for 12 mo…

This study is testing whether eating almonds can help heal broken thigh and shin bones as effectively as vitamin D supplements, but with fewer side effects and lower cost. The trial will include 136 adults with these fractures, who will receive either almonds, vitamin D, or both,…

Open tibia fractures break the skin and expose bone, which lets bacteria in and leads to infections that can cause disability. Researchers in Tanzania are testing whether applying the antibiotic gentamicin directly to the wound during surgery prevents infection better than saline…

This study tests whether coating a metal rod (intramedullary nail) with antibiotics (vancomycin and gentamicin) can prevent deep infections in people with severe open tibia fractures. About 484 adults with Gustilo Type II or III open tibia fractures will be randomly assigned to r…

This study tests whether placing an antibiotic depot directly into the bone during surgery can prevent infections in people with severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to get either the antibiotic depot plus stan…

Researchers are testing whether a structured rehabilitation program works better than usual physiotherapy for adults recovering from surgery to fix a traumatic tibial fracture. The program guides progression through four phases using set clinical and functional criteria, while re…

This study tests a device called the Verus frame, which supports the leg during surgery to fix a broken shinbone. The goal is to see if it helps surgeons align the bone more accurately. Twenty-five adults with tibial fractures will be enrolled, and their results will be compared …

This study looks at whether using a continuous passive motion (CPM) machine—a device that gently moves the leg—can help control pain and reduce the need for strong painkillers after surgery for certain leg fractures. About 100 adults who have had surgery for a broken hip socket, …

This study looks at whether starting physical therapy soon after surgery for a specific knee fracture (tibial spine avulsion) helps people recover better than waiting longer. It includes 56 people aged 15-25 who had the surgery. Researchers will measure knee movement, muscle stre…

This study tests whether a nerve block (numbing medication injected near knee nerves) can control pain better than the usual method of numbing just the surgical cut. Researchers will compare pain scores and painkiller use in 38 adults recovering from surgery for a broken shinbone…

This study tests whether a 12-week course of a cetylated fatty acid supplement can improve bone healing after surgery for a broken femur or tibia. One hundred adults will receive either the supplement or a placebo, and healing will be tracked with X-rays and pain scores. The goal…

This study compares two types of physical therapy for people with a broken shinbone. One group will do low-weight exercises while wearing a blood flow restriction cuff on their leg. The other group will do the same exercises without the cuff. Researchers will measure muscle stren…

This study looks at whether a small pressure sensor placed in the leg during surgery can help doctors spot a rare but serious problem called acute compartment syndrome. Teens aged 10 to 21 with a broken shinbone will have the sensor monitor pressure for at least 18 hours after th…

This pilot study will use a very small camera, called a nano-arthroscope, to look inside the ankle joint of 25 people who have a severe type of ankle fracture (pilon fracture). The goal is to find out how often hidden cartilage injuries occur and whether seeing them changes the s…

This study compares two types of metal rods used to fix broken shin bones (tibia fractures). One rod allows tiny movements at the fracture site, while the other is standard. Researchers want to see which rod helps bones heal better and causes fewer problems. About 372 adults with…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study tests a new computer tool that creates a 3D model of a broken shinbone to help surgeons plan where to place screws and plates before surgery. The tool uses the patient's own CT scan to simulate different repair options. About 40 adults with a lower leg fracture will ta…