Thyroid gland disorder

This trial tests whether an oral medication called linsitinib can help people with active, moderate to severe thyroid eye disease, a condition that causes eye bulging and inflammation. Participants take either linsitinib or a placebo twice daily for 24 weeks. The main goal is to …

This trial tests a new way to personalize the dose of levothyroxine, a thyroid hormone medication, for people who have had surgery for thyroid cancer. Using mathematical and statistical models, the approach aims to predict the best dose for each individual, potentially reducing s…

This study tests whether using a low electrical current (3 or 5 milliamps) during thyroid surgery helps surgeons locate and avoid damaging the nerve that controls the voice box. About 150 adults having their first thyroid surgery will be randomly assigned to one of two current le…

This study tested the drug cabozantinib in 41 adults with advanced differentiated thyroid cancer that no longer responds to radioactive iodine treatment. Participants took a 60 mg pill daily until their cancer worsened or side effects became too severe. The main goal was to under…

This study compared two ways to control bleeding during total thyroidectomy: using a device called LigaSure versus traditional knot tying. Researchers looked at whether LigaSure caused fewer injuries to the nerve that controls the voice box. The study involved 120 patients aged 1…

This study tested a new medicine called MBX 2109, given once a week as a shot, in 64 adults with hypoparathyroidism. The goal was to see if it could safely help patients reduce their daily calcium and vitamin D pills while keeping blood calcium levels normal. The trial was comple…

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study tests whether giving dexmedetomidine—either as a nasal spray or through an IV—before thyroid surgery can improve sleep quality afterward. 120 adults undergoing thyroid removal will be randomly assigned to one of two drug groups or a placebo. The goal is to see if this …

This study tested a new method called the 'Huaxi Tunnel Technique' to protect the recurrent laryngeal nerve during thyroid surgery. The technique uses a diluted epinephrine solution injected along the nerve to create a protective tunnel, reducing the risk of injury. The trial inv…

This trial tests whether a daily supplement called Hello Burn, Balance can improve symptoms linked to hormone imbalance, such as low energy and unhealthy eating habits. Forty women aged 25 and older will take the supplement for four weeks and report their symptoms through questio…

This study tests whether a mobile app that provides education and support before and after thyroid surgery can improve recovery and quality of life. Participants are adults having their first thyroidectomy who own a smartphone. One group gets standard care, while the other also u…

This trial investigates whether placing a small piece of absorbable material (oxidized regenerated cellulose) over the nerves that control the voice box during total thyroidectomy can improve early voice quality. Thirty adults scheduled for thyroid surgery will be randomly assign…

This study tests whether a mobile app providing education based on the Life Model can help reduce anxiety and improve daily living activities in people who have had their thyroid gland removed for benign disease. About 68 participants will either receive standard discharge instru…

This study looked at whether removing benign thyroid nodules without placing a surgical drain is safe and effective. Eighty adults having thyroid surgery were randomly assigned to either the standard drain or a no-drain, sutureless technique. The goal was to see if the no-drain a…

This study tested a special recovery program (ERAS) for people having thyroid surgery. The goal was to see if it could reduce pain, nausea, and time spent in the hospital compared to usual care. 143 adults took part, and the program focused on improving comfort and speeding up re…

This study looks at how thyroid problems impact pain, tiredness, foot shape, muscle strength, and leg function in women who have regular periods. Researchers will compare 51 women with thyroid issues to healthy women to see what differences exist. The goal is to better understand…

This study investigates whether using a personalized electrical current to monitor the nerve that controls the vocal cords during thyroid surgery is as effective as the standard fixed current. Researchers will analyze data from over 600 patients to see if individualizing the stim…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This study tested whether a newer 3D imaging method (SPECT/CT) is as accurate as the standard 2D method for measuring how much the thyroid gland takes up a radioactive tracer. 27 people with underactive or overactive thyroids were scanned with both methods. The goal was to see if…

This small study tested whether injecting a fluorescent dye called fluorescein sodium helps surgeons see nerves during head and neck surgery. Eight adults having open head or neck surgery received the dye through an IV. Surgeons then rated how well the glowing nerves matched stan…

This completed study from the University of Pisa looked at how the thyroid cancer drug selpercatinib affects body composition. Fifteen adults on the drug had their lean mass and energy expenditure measured. The goal was simply to observe and gather data, not to test a new treatme…

This study looked at 170 adults having thyroid surgery under general anesthesia to see if the blood pressure difference between the arm and leg changes when they are asleep. Researchers measured blood pressure in both limbs before and during anesthesia. The goal was to understand…

This completed study collected extra blood samples from 28 adults with thyroid disorders to help standardize thyroid-stimulating hormone (TSH) tests. Different labs often use different tests, making it hard to compare results. By analyzing these samples, researchers hope to make …

This study examined whether a marker of inflammation called interleukin-6 (IL-6) is linked to thyroid hormone problems in people with chronic kidney disease on dialysis. Researchers analyzed blood samples from 65 stable dialysis patients. The goal was to see if higher IL-6 levels…

This study looked at how changing the head position during thyroid surgery affects the optic nerve sheath diameter, which can indicate pressure inside the skull. Researchers measured this with ultrasound in 49 patients before and after positioning. They also tracked headache seve…

This study tested a special radioactive substance called 124-Iodine to see how much radiation each thyroid cancer spot in the body receives. The goal was to help doctors decide the right dose of standard treatment (131-Iodine) and avoid giving unnecessary radiation to patients wh…

This study looked at 50 adults having thyroid or parathyroid surgery to see how quickly the muscle relaxant rocuronium wears off. Doctors need the drug to be gone so they can monitor a nerve that controls the voice box during surgery. The goal was to find the best timing for givi…