Water jet technique shields voice nerve in thyroid surgery
NCT ID NCT07298616
First seen Jun 25, 2026 · Last updated Aug 20, 2026 · Updated 4 times
Summary
This study tested a new method called the 'Huaxi Tunnel Technique' to protect the recurrent laryngeal nerve during thyroid surgery. The technique uses a diluted epinephrine solution injected along the nerve to create a protective tunnel, reducing the risk of injury. The trial involved 238 patients undergoing open thyroid surgery and compared this method to traditional dissection. The goal was to lower the chance of voice problems after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- diluted epinephrine solution
- What this could lead to
- If successful, this technique could make thyroid surgery safer by reducing the risk of nerve injury and voice problems.
- What could go wrong
- This is a completed trial with 238 participants, but the technique is new and may not be widely adopted. Results may vary by surgeon experience.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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238 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18-75 years, regardless of gender； * Patients hospitalized for open thyroid surgery (undergoing at least unilateral lobe and isthmus resection) and undergoing the procedure for the first time； * Preoperative color Doppler or contrast-enhanced ultrasound assessment indicates no significant invasion of the recurrent laryngeal nerve by the lesion； * Participants voluntarily agree to join the trial and provide signed informed consent. Exclusion Criteria: * History of thyroid nodule ablation therapy; * Patients scheduled for lateral neck dissection; * History of hypertension, atrial fibrillation, or severe arrhythmia; * Uncontrolled subacute thyroiditis or hyperthyroidism; * Severe comorbidities affecting major organs (cardiac, pulmonary, hepatic, or renal); * Presence of cancer-related cachexia syndrome; * History of psychiatric disorders or cognitive impairment; * Pregnant or lactating women; * Participation in other clinical trials within 90 days; * Other conditions deemed by investigators as unsuitable for trial participation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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West China hospital of Sichuan University
Chengdu, Sichuan, 610041, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.