Thrombotic disease

This study tests a needle-free connector with anti-reflux technology, a special stopper that prevents blood from flowing back into IV catheters. The goal is to see if it reduces complications like blockages, infections, and pain compared to standard connectors. The trial will inv…

This study looks at whether a special blood test (TEG-PM) can guide doctors in adjusting blood-thinning medications for people who have had leg artery surgery for peripheral artery disease. About 130 adults will have their blood tested before and up to 9 months after surgery, and…

This Phase 2 trial tests whether delivering the anti-inflammatory drug dexamethasone directly around deep veins can prevent blood clots from returning after they are removed. The study involves 60 adults aged 18-89 who have had DVT symptoms for 14-60 days. Participants receive ei…

This early-phase trial tests an investigational biologic called EA5 in adults with antiphospholipid syndrome (APS) who have had two or more blood clots despite standard blood-thinning therapy. The study enrolls about 12 participants and gives EA5 by intravenous infusion followed …

This phase 2 trial tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal is safe and feasible for people with severe stroke. About 40 participants who had a large artery blockage will receive either the drug or a saltwa…

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study was designed to test a special catheter that delivers clot-dissolving medicine directly into the lungs of people with blood clots. The trial was withdrawn before enrolling any participants, so no results are available. It would have included adults aged 18 to 80 with s…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This study was designed to test a device called LAmbre Plus, which is implanted to seal off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to see if it could safely prevent strokes in patients with large or irregularly shaped hear…

Antiphospholipid syndrome (APS) raises the risk of blood clots and strokes, and doctors often prescribe warfarin to prevent another stroke. Warfarin requires frequent blood tests and carries bleeding risks, especially for younger patients. This trial compares clopidogrel-based an…

This study looks at how the common sweetener erythritol affects blood clotting and blood vessel health compared to aspartame. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with each sweetener for two weeks. Researchers will measure markers of platel…

This pilot study is testing whether a specialized blood test called thromboelastography (TEG) can better evaluate clotting problems in people with severe burns. Researchers will track clotting patterns over the first four weeks after injury and see if they relate to burn size or …

This study explores whether a special 3D ultrasound technique, called vector flow imaging, can predict where blood clots form inside abdominal aortic aneurysms. Researchers will scan 14 people with small aneurysms (under 5.5 cm), half with existing clots and half without. They wi…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study aimed to see if a non-invasive finger cuff monitor could track heart function in people with a pulmonary embolism (a blood clot in the lung). The device measures stroke volume and cardiac output continuously, which might help doctors detect early signs of heart failure…

This study looked back at medical records from 2000 adults hospitalized with a blood clot in the lungs (pulmonary embolism). Researchers collected lab tests and CT scan results to see which patients later had serious problems like death, needing a breathing machine, or emergency …

This study reviews the medical records of 500 people who had surgery on major arteries (not heart surgery). It aims to see if taking blood thinners (antiplatelet or anticoagulant drugs) around the time of surgery affects the chance of bleeding or blood clots. The researchers comp…

This study looks at 600 adults who take blood thinners and have a mild head injury but a normal first brain scan. Researchers want to know how often a delayed brain bleed happens within 24 hours and up to 4 weeks after the injury. They also track risks like blood clots or confusi…