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New hope for chronic leg pain: catheter procedure could reduce Post-Clot disability

NCT ID NCT03250247

First seen Nov 03, 2025 · Last updated Jun 17, 2026 · Updated 26 times

Summary

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus standard care or standard care alone. The goal is to see if the procedure improves leg symptoms, quality of life, and ulcer healing.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Christiana Care Hospital

    Newark, Delaware, 19718, United States

  • Gundersen Health System

    La Crosse, Wisconsin, 54601, United States

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Jobst Vascular Institute

    Toledo, Ohio, 43606, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • New York Presbyterian-Weill Cornell Medicine

    NewYork, New York, 10065, United States

  • New York University Medical Center

    New York, New York, 10003, United States

  • NorthShore University Health System

    Evanston, Illinois, 60201, United States

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Oregon Health & Sciences University

    Portland, Oregon, 97239, United States

  • Rush Medical Center

    Chicago, Illinois, 60612, United States

  • St. Elizabeth's Hospital

    Lincoln, Nebraska, 68510, United States

  • St. Joseph's Vascular Institute

    Orange, California, 92868, United States

  • Staten Island Hospital

    Staten Island, New York, 10305, United States

  • Temple University

    Philadelphia, Pennsylvania, 19140, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • UCSF

    San Francisco, California, 94143, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of North Carolina

    Chapel Hill, North Carolina, 27517, United States

  • University of Oklahoma

    Oklahoma City, Oklahoma, 73014, United States

  • University of Pittsburg

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Vermont Health Network - CVPH

    Plattsburgh, New York, 12901, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06510, United States

Conditions

The condition(s) this trial relates to.

post-thrombotic syndrome Postthrombotic Syndrome thrombotic disease ulcer of lower limbs Varicose Ulcer venous insufficiency venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.