Panic disorder

This study tests whether an AI-based decision support tool can help therapists deliver internet-based cognitive behavioural therapy (iCBT) for depression, panic disorder, and social anxiety. About 400 adults with these conditions will receive 12 weeks of iCBT, with therapists usi…

This study tests whether a type of talk therapy called cognitive behavioral therapy (CBT) can help teenagers with panic disorder. The therapy includes 11 weekly sessions designed to change how teens think about and react to panic symptoms. Participants track their anxiety daily. …

This study tests whether an intensive, 8-day form of cognitive behavioral therapy (CBT) can help adolescents with panic disorder and agoraphobia. The therapy includes 15-20 hours of one-on-one sessions focused on changing anxious thoughts and gradually facing feared situations. S…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This study tested whether adding mental health care (like therapy and education) to standard job support helps people on sick leave due to anxiety or depression return to work sooner. Over 600 participants in Denmark were randomly assigned to one of two programs or usual care. Th…

This trial tests whether a 6-session therapy called Imagery Rescripting (ImRs) can reduce panic disorder symptoms by changing how people recall and process traumatic panic attack memories. Adults diagnosed with panic disorder are randomly assigned to receive the therapy or be in …

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This pilot study tested a new type of brain stimulation, called accelerated intermittent theta burst stimulation (aiTBS), for people with anxiety disorders or PTSD. Fifteen participants received the non-invasive treatment targeting a novel brain area. The study measured changes i…

This study looked at whether different intensities of exercise can reduce anxiety in adults with anxiety disorders. 110 sedentary adults with high anxiety sensitivity were assigned to either low-intensity exercise or a program that gradually increased to high-intensity exercise o…

This study tested whether a 6-week group therapy program (cognitive behaviour therapy) could help reduce anxiety and stress in pregnant women and new mothers. 72 women from Manitoba, Canada, who were pregnant or within 12 months postpartum and had an anxiety disorder took part. T…

This study tested an internet-based cognitive behavioral therapy (CBT) program called AMTE for adolescents with anxiety and depression. Sixty teens were randomly assigned to either the online program or a control group. The goal was to see if the program could reduce symptoms of …

This study tested a brief form of cognitive behavioral therapy (bCBT) for Veterans with anxiety. 225 Veterans from three VA medical centers received either bCBT (in-person or by video) or usual care. The goal was to see if this short therapy helps reduce anxiety symptoms better t…

This study tested a handheld device called CalmiGo in 35 adults coming to the emergency department with anxiety or panic attacks. The device uses guided breathing, aromatherapy, and grounding techniques to help people relax without medication. Researchers measured symptoms before…

This study tested a mobile app that delivers cognitive behavioral therapy (CBT) on its own for adults whose panic disorder hasn't improved with standard treatments. 45 participants used the app for eight weeks, covering skills like relaxation and changing unhelpful thoughts. The …

This study tested a new way of delivering care for people with anxiety and depression in Danish general practices. 302 adults with conditions like panic disorder, social anxiety, or PTSD took part. The model involved a team of doctors, nurses, and therapists working together, and…

This study tested whether a collaborative care model, called Collabri, works better than usual treatment for people with anxiety. The model involves a team including a care manager, general practitioner, and psychiatrist, with regular monitoring and a structured plan. 406 adults …

This study tested a new type of group therapy that combines standard cognitive behavioral therapy with religious values like gratitude and trust. Researchers compared it to regular therapy and a control group in 33 young adults with anxiety. The goal was to see if the faith-based…

This study tested whether a self-guided app could work as well as traditional therapy for panic disorder. 46 adults were split into two groups: one received standard cognitive behavioral therapy, and the other used an app with the same 8-session plan. Both groups were assessed fo…

This study tested whether a single therapy (Transdiagnostic Behavior Therapy) works as well as separate, disorder-specific therapies for veterans with PTSD, major depression, or panic disorder. 304 veterans participated, and researchers measured symptoms before, during, and after…

This study tested a new program called Adjunctive Family-Cognitive Behavioral Therapy (AF-CBT) for veterans with anxiety disorders. It involved 48 veterans and their family members to see if adding family support to standard therapy was acceptable and helpful. The main goal was t…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study looks at whether certain immune system markers (IL-33, sST2, and CRP) are different in people with panic disorder compared to healthy individuals. Researchers will measure these markers in blood samples from 80 participants who have never taken medication for panic dis…

This study investigates what makes cognitive-behavioral therapy effective for children and teens aged 7 to 16 with anxiety or depression. Researchers will analyze therapy sessions and outcomes to identify which techniques and processes lead to improvement. The goal is to understa…

This study looked at levels of a specific enzyme, α-N-acetylgalactosaminidase, in the blood of people with panic disorder who had never taken medication. Researchers compared these levels to healthy individuals and checked for connections with symptom severity and inflammation. T…

This completed study from the University of Toronto looked at whether certain gut bacteria are linked to anxiety, depression, and panic disorders. 500 adults provided stool samples to test for H. pylori and other bacteria. The goal was to understand possible root causes, not to t…

This study looked at how a 250 mg caffeine pill (about 2-3 cups of coffee) affects anxiety, decision-making, and body awareness in 42 people—some with panic disorder and some healthy. Participants took caffeine or a placebo on different days while having their brain scanned in a …

This study looked at whether exercise helps adults with high anxiety and anxiety disorders (like generalized anxiety, panic, or social anxiety) better learn to unlearn fear. 54 participants either exercised or sat quietly after a fear-extinction task. Researchers measured skin sw…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This study tested whether real-time fMRI neurofeedback can help people with anxiety disorders better regulate their emotions. 21 participants practiced cognitive reappraisal while receiving feedback on their prefrontal cortex activity. The goal was to understand the brain mechani…

This study followed 559 children and teens ages 6 to 19 in the McLean Anxiety Mastery Program to see if their anxiety and depression improved with treatment. Researchers compared patients who received treatment to those on a waitlist and checked if gains lasted three months after…